Gene Mutations in Patients With Advanced Prostate Cancer That Is Not Responsive to Hormone Therapy



Status:Completed
Conditions:Prostate Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:4/21/2016
Start Date:January 1997
End Date:June 2006

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Trial Summary
Trial Overview
Inclusion Criteria

Androgen Receptor Mutations in Hormone Refractory Prostate Cancer

RATIONALE: Gene mutations may make prostate cancer cells unable to attach to androgens. This
may permit the growth of prostate cancer. Gene testing may improve the identification of
patients with advanced prostate cancer.

PURPOSE: Clinical trial to study the androgen receptor gene in patients with prostate cancer
that is not responsive to hormone therapy.

OBJECTIVES:

1. the feasibility of collecting bone marrow biopsies from prostate cancer patients in a
cooperative group setting

2. the incidence of marrow invasion by prostate tumor in random bone marrow biopsy

3. the influence of previous prostate radiation on obtaining prostate tumor

4. the frequency and type of AR mutations and

5. association of AR mutations with response to antiandrogen withdrawal.

1. Histologically proven adenocarcinoma of the prostate that is refractory to hormone
therapy

2. Patients who are eligible for anticancer therapy on Protocol CLB-9480, CLB-9583,
CLB-9680, or CLB-9780 are also eligible for this study if they have not started
treatment on those protocols
We found this trial at
49
sites
Duke Comprehensive Cancer Center
125 Science Dr
Durham, North Carolina 27710
888.275.3853
Duke Comprehensive Cancer Center Leading-edge cancer care and research have been a hallmark of Duke...
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Durham, NC
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Roswell Park Cancer Institute
666 Elm Street
Buffalo, New York 14263
(716) 845-2300
Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
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Buffalo, NY
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CCOP - North Shore University Hospital
300 Community Drive
Manhasset, New York 11030
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Manhasset, NY
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North Shore University Hospital
300 Community Drive
Manhasset, New York 11030
(516) 562-0100
North Shore University Hospital North Shore-LIJ Health System includes 16 award-winning hospitals and nearly 400...
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Manhasset, NY
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University of Tennessee, Memphis Cancer Center
1331 Union Ave # 800
Memphis, Tennessee 38103
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Memphis, TN
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Mount Sinai Medical Center CCOP
4300 Alton Road
Miami Beach, Florida 33140
(305) 674-2625
CCOP - Mount Sinai Medical Center The Mount Sinai Community Clinical Oncology Program (MSCCOP) is...
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Miami Beach, FL
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Rhode Island Hospital
593 Eddy Street
Providence, Rhode Island 02903
401-444-4000
Rhode Island Hospital Founded in 1863, Rhode Island Hospital in Providence, RI, is a private,...
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Providence, RI
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Marlene & Stewart Greenebaum Cancer Center, University of Maryland
Baltimore, Maryland 21201
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Baltimore, MD
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Veterans Affairs Medical Center - Birmingham
700 19th Street South
Birmingham, Alabama 35233
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Birmingham, AL
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Dana-Farber Cancer Institute
450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Boston, MA
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Veterans Affairs Medical Center - Buffalo
Buffalo, New York 14215
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Buffalo, NY
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Lineberger Comprehensive Cancer Center, UNC
Chapel Hill, North Carolina 27599
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Chapel Hill, NC
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Medical University of South Carolina
171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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Charleston, SC
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University of Illinois at Chicago Health Sciences Center
Chicago, Illinois 60612
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Chicago, IL
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Veterans Affairs Medical Center - Chicago Westside Hospital
Chicago, Illinois 60612
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Chicago, IL
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University of Chicago Cancer Research Center
Chicago, Illinois 60637
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Chicago, IL
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Veterans Affairs Medical Center - Columbia (Truman Memorial)
Columbia, Missouri 65201
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Columbia, MO
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Ellis Fischel Cancer Center - Columbia
Columbia, Missouri 65203
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Columbia, MO
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Arthur G. James Cancer Hospital - Ohio State University
Columbus, Ohio 43210
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Columbus, OH
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Veterans Affairs Medical Center - Durham
Durham, North Carolina 27705
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Durham, NC
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University of Iowa Hospitals and Clinics
200 Hawkins Dr,
Iowa City, Iowa 52242
866-452-8507
University of Iowa Hospitals and Clinics University of Iowa Hospitals and Clinics—recognized as one of...
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Iowa City, IA
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University of California San Diego Cancer Center
La Jolla, California 92093
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La Jolla, CA
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CCOP - Southern Nevada Cancer Research Foundation
Las Vegas, Nevada 89106
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Las Vegas, NV
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Norris Cotton Cancer Center
Lebanon, New Hampshire 03756
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Lebanon, NH
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St. Barnabas Medical Center
Livingston, New Jersey 07039
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Livingston, NJ
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Veterans Affairs Medical Center - Memphis
Memphis, Tennessee 38104
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Memphis, TN
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Veterans Affairs Medical Center - Minneapolis
Minneapolis, Minnesota 55417
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Minneapolis, MN
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University of Minnesota Cancer Center
Minneapolis, Minnesota 55455
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Minneapolis, MN
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Memorial Sloan Kettering Cancer Center
1275 York Ave
New York, New York 10021
(212) 639-2000
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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New York, NY
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The New York Presbyterian Hospital - Cornell Campus
New York, New York 10021
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New York, NY
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Mount Sinai Medical Center, NY
New York, New York 10029
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New York, NY
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Univ of Nebraska Med Ctr
Emile St
Omaha, Nebraska 68198
(402) 559-4000
Univ of Nebraska Med Ctr A vital enterprise in the nation’s heartland, the University of...
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Omaha, NE
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St. Joseph's Hospital and Medical Center
Paterson, New Jersey 07503
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Paterson, NJ
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Veterans Affairs Medical Center - Richmond
Richmond, Virginia 23249
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Richmond, VA
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MBCCOP - Massey Cancer Center
Richmond, Virginia 23298
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Richmond, VA
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Barnes Jewish Hospital
Saint Louis, Missouri 63110
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Saint Louis, MO
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UCSF Cancer Center and Cancer Research Institute
San Francisco, California 94143
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San Francisco, CA
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Veterans Affairs Medical Center - San Francisco
San Francisco, California 94121
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San Francisco, CA
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CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
Syracuse, New York 13217
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Syracuse, NY
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State University of New York Upstate Medical University
Syracuse, New York 13214
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Syracuse, NY
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Veterans Affairs Medical Center - Syracuse
Syracuse, New York 13210
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Syracuse, NY
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Veterans Affairs Medical Center - Togus
Togus, Maine 04330
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Togus, ME
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Vincent T. Lombardi Cancer Research Center, Georgetown University
3700 O Street Northwest
Washington, District of Columbia 20007
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Washington,
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Walter Reed Army Medical Center
6900 Georgia Ave NW
Washington, District of Columbia 20307
(202) 782-6849
Walter Reed Army Medical Center The Walter Reed National Military Medical Center is one of...
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Washington,
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Veterans Affairs Medical Center - White River Junction
White River Junction, Vermont 05009
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White River Junction, VT
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CCOP - Christiana Care Health Services
Wilmington, Delaware 19899
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Wilmington, DE
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CCOP - Southeast Cancer Control Consortium
Winston-Salem, North Carolina 27104
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Winston-Salem, NC
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Comprehensive Cancer Center of Wake Forest University Baptist Medical Center
Winston-Salem, North Carolina 27157
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Winston-Salem, NC
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University of Massachusetts Memorial Medical Center
Worcester, Massachusetts 01655
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Worcester, MA
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