Surgery in Treating Patients With Prostate Cancer



Status:Completed
Conditions:Prostate Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any - 75
Updated:4/21/2016
Start Date:May 1997
End Date:January 2010

Use our guide to learn which trials are right for you!

The Role of Salvage Prostatectomy for Radiation Failure in Prostate Carcinoma: A Phase II Trial

RATIONALE: Prostatectomy may be an effective treatment for prostate cancer that has not
responded to radiation therapy.

PURPOSE: This phase II trial is studying how well prostatectomy works in treating patients
with recurrent or persistent prostate cancer that has not responded to radiation therapy.

OBJECTIVES:

- Determine the characteristics of failure-free survival, disease-free survival, overall
survival, surgical morbidity and mortality, and quality of life of patients treated
with salvage prostatectomy for the recurrence of persistent disease after treatment
with prior radiotherapy for localized prostate cancer.

- Develop expertise in the use of salvage prostatectomy prior to a possible phase III
trial of salvage prostatectomy in this population versus a control arm such as hormonal
therapy or cryotherapy.

- Determine the quality of life measures in these patients.

- Determine the preliminary data on the quality of life of patients undergoing salvage
radical prostatectomy and use the data to design a phase III study.

- Determine the histologic and morphometric characterization of the carcinoma.

OUTLINE: Patients undergo modified bilateral pelvic lymph node dissection.

Patients with negative nodes undergo salvage prostatectomy via either retropubic or perineal
approach. Patients with positive nodes may undergo radical prostatectomy at the discretion
of the investigator.

Postoperative hormonal therapy may be given at time of symptomatic disease progression or a
newly positive bone scan, or for a consistently rising prostate-specific antigen. Adjuvant
hormonal therapy is also allowed.

Quality of life is assessed prior to surgery and at 3, 6, 12, 18, and 24 months after
surgery.

Patients are followed at least every 3 months for 2 years, every 6 months for 2 years, and
then annually thereafter.

PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study within 2 years.

DISEASE CHARACTERISTICS:

- Histologically proven recurrent or persistent prostate cancer

- Prostate-specific antigen (PSA) no greater than 20 ng/mL

- Must have been previously treated with at least 60 cGy of external beam radiotherapy
or brachytherapy for clinical stages T1-2NXM0 with PSA no greater than 30 ng/mL

- No metastatic disease at time of biopsy

PATIENT CHARACTERISTICS:

Age:

- 75 and under

Performance status:

- CALGB (Zubrod) 0-1

Life expectancy:

- At least 5-10 years

Other:

- No other "currently Temporarily closed" malignancy except nonmelanoma skin cancer

- Patients are not considered to have a "currently Temporarily closed" malignancy
if they have completed therapy and are considered to be at less than 30% risk of
relapse

PRIOR CONCURRENT THERAPY:

Endocrine therapy:

- At least 3 months since prior adjuvant hormonal therapy

Radiotherapy:

- See Disease Characteristics

- At least 18 months since prior external beam or interstitial radiotherapy
We found this trial at
61
sites
Paterson, New Jersey 07503
1278
mi
from
Paterson, NJ
Click here to add this to my saved trials
666 Elm Street
Buffalo, New York 14263
(716) 845-2300
Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
1057
mi
from
Buffalo, NY
Click here to add this to my saved trials
115 Business loop 70 w
Columbia, Missouri 65203
(573) 882-2100
Ellis Fischel Cancer Center at University of Missouri - Columbia At Ellis Fischel Cancer Center,...
308
mi
from
Columbia, MO
Click here to add this to my saved trials
125 Science Dr
Durham, North Carolina 27710
888.275.3853
Duke Comprehensive Cancer Center Leading-edge cancer care and research have been a hallmark of Duke...
1051
mi
from
Durham, NC
Click here to add this to my saved trials
1150 N 35th Ave # 330
Hollywood, Florida 33021
1310
mi
from
Hollywood, FL
Click here to add this to my saved trials
200 Hawkins Drive
Iowa City, Iowa 52242
800-237-1225
Holden Comprehensive Cancer Center at University of Iowa Holden Comprehensive Cancer Center is dedicated to...
429
mi
from
Iowa City, IA
Click here to add this to my saved trials
One Medical Center Drive
Lebanon, New Hampshire 03756
(603) 653-9000
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center Norris Cotton Cancer Center at DHMC in...
1393
mi
from
Lebanon, NH
Click here to add this to my saved trials
300 Community Drive
Manhasset, New York 11030
1302
mi
from
Manhasset, NY
Click here to add this to my saved trials
300 Community Drive
Manhasset, New York 11030
(516) 562-0100
North Shore University Hospital North Shore-LIJ Health System includes 16 award-winning hospitals and nearly 400...
1302
mi
from
Manhasset, NY
Click here to add this to my saved trials
4300 Alton Road
Miami Beach, Florida 33140
(305) 674-2625
CCOP - Mount Sinai Medical Center The Mount Sinai Community Clinical Oncology Program (MSCCOP) is...
1322
mi
from
Miami Beach, FL
Click here to add this to my saved trials
1300 York Avenue # A421
New York, New York 10065
New York Weill Cornell Cancer Center at Cornell University Welcome to the Division of Hematology...
1289
mi
from
New York, NY
Click here to add this to my saved trials
1 Gustave L Levy Pl # 271
New York, New York 10029
 (212) 241-6500
Mount Sinai Med Ctr Founded in 1852, The Mount Sinai Hospital is a 1,171-bed, tertiary-care...
1289
mi
from
New York, NY
Click here to add this to my saved trials
985950 Nebraska Medical Center
Omaha, Nebraska 68198
402-559-4090
UNMC Eppley Cancer Center at the University of Nebraska Medical Center The Fred & Pamela...
259
mi
from
Omaha, NE
Click here to add this to my saved trials
34800 Bob Wilson Dr,
San Diego, California 92134
(619) 532-6400
Naval Medical Center - San Diego We are the largest and most comprehensive military healthcare...
1142
mi
from
San Diego, CA
Click here to add this to my saved trials
750 E Adams St
Syracuse, New York 13210
(315) 464-5540
SUNY Upstate Medical University Hospital SUNY Upstate Medical University in Syracuse, NY, is the only...
1194
mi
from
Syracuse, NY
Click here to add this to my saved trials
729
mi
from
Anniston, AL
Click here to add this to my saved trials
Asheville, North Carolina 28805
860
mi
from
Asheville, NC
Click here to add this to my saved trials
1148
mi
from
Baltimore, MD
Click here to add this to my saved trials
1441
mi
from
Boston, MA
Click here to add this to my saved trials
1356
mi
from
Burlington, VT
Click here to add this to my saved trials
1227
mi
from
Camden, NJ
Click here to add this to my saved trials
101 Manning Drive
Chapel Hill, North Carolina 27514
(919) 966-0000
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill One of the...
1038
mi
from
Chapel Hill, NC
Click here to add this to my saved trials
Charlottesville, Virginia 22901
1053
mi
from
Charlottesville, VA
Click here to add this to my saved trials
609
mi
from
Chicago, IL
Click here to add this to my saved trials
Chicago, Illinois 60640
611
mi
from
Chicago, IL
Click here to add this to my saved trials
Concord, North Carolina 28025
968
mi
from
Concord, NC
Click here to add this to my saved trials
353
mi
from
Dallas, TX
Click here to add this to my saved trials
1197
mi
from
East Syracuse, NY
Click here to add this to my saved trials
Elmhurst, New York 11373
1293
mi
from
Elmhurst, NY
Click here to add this to my saved trials
Fayetteville, North Carolina 28302
1076
mi
from
Fayetteville, NC
Click here to add this to my saved trials
Fort Lauderdale, Florida 33316
1309
mi
from
Fort Lauderdale, FL
Click here to add this to my saved trials
718
mi
from
Fort Wayne, IN
Click here to add this to my saved trials
Goldsboro, North Carolina 27534
1110
mi
from
Goldsboro, NC
Click here to add this to my saved trials
200 Technology Drive
Hooksett, New Hampshire 03106
603-622-6484
New Hampshire Oncology - Hematology, PA - Hooksett New Hampshire Oncology-Hematology, PA (NHOH) was founded...
1428
mi
from
Hooksett, NH
Click here to add this to my saved trials
Huntington, West Virginia 25702
840
mi
from
Huntington, WV
Click here to add this to my saved trials
Jamaica, New York 11432
1297
mi
from
Jamaica, NY
Click here to add this to my saved trials
Kansas City, Missouri 64131
195
mi
from
Kansas City, MO
Click here to add this to my saved trials
Kinston, North Carolina 28503
1134
mi
from
Kinston, NC
Click here to add this to my saved trials
La Jolla, California 92093
1142
mi
from
La Jolla, CA
Click here to add this to my saved trials
961
mi
from
Las Vegas, NV
Click here to add this to my saved trials
961
mi
from
Las Vegas, NV
Click here to add this to my saved trials
Louisville, Kentucky 40207
663
mi
from
Louisville, KY
Click here to add this to my saved trials
1275 York Ave
New York, New York 10021
(212) 639-2000
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
1289
mi
from
New York, NY
Click here to add this to my saved trials
4701 Ogletown-Stanton Road
Newark, Delaware 19713
302-623-4450
CCOP - Christiana Care Health Services Christiana Care's Cancer Research Program is part of a...
1195
mi
from
Newark, DE
Click here to add this to my saved trials
Norfolk, Virginia 23502
1186
mi
from
Norfolk, VA
Click here to add this to my saved trials
Oklahoma City, Oklahoma 73104
158
mi
from
Oklahoma City, OK
Click here to add this to my saved trials
485
mi
from
Peoria, IL
Click here to add this to my saved trials
1033
mi
from
Pinehurst, NC
Click here to add this to my saved trials
Providence, Rhode Island 02906
1424
mi
from
Providence, RI
Click here to add this to my saved trials
Richmond, Virginia 23298
1113
mi
from
Richmond, VA
Click here to add this to my saved trials
River Forest, Illinois 60305
602
mi
from
River Forest, IL
Click here to add this to my saved trials
981
mi
from
Roanoke, VA
Click here to add this to my saved trials
670
mi
from
Saint Joseph, MI
Click here to add this to my saved trials
415
mi
from
Saint Louis, MO
Click here to add this to my saved trials
San Diego, California 92161
1142
mi
from
San Diego, CA
Click here to add this to my saved trials
San Francisco, California 94115
1340
mi
from
San Francisco, CA
Click here to add this to my saved trials
6900 Georgia Ave NW
Washington, District of Columbia 20307
(202) 782-6849
Walter Reed Army Medical Center The Walter Reed National Military Medical Center is one of...
1127
mi
from
Washington,
Click here to add this to my saved trials
Washington, District of Columbia 20422
1127
mi
from
Washington,
Click here to add this to my saved trials
1135
mi
from
Wilmington, NC
Click here to add this to my saved trials
Medical Center Boulevard
Winston-Salem, North Carolina 27157
336-716-2255
Comprehensive Cancer Center of Wake Forest University Our newly expanded Comprehensive Cancer Center is the...
979
mi
from
Winston-Salem, NC
Click here to add this to my saved trials
Worcester, Massachusetts 01655
1405
mi
from
Worcester, MA
Click here to add this to my saved trials