Genetic Study in Patients With Stage II or Stage III Colon Cancer
| Status: | Completed |
|---|---|
| Conditions: | Colorectal Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any - 69 |
| Updated: | 7/14/2016 |
| Start Date: | February 1999 |
| End Date: | August 2006 |
The Clinical and Pathological Significance of Allelic Imbalance of 8p in Patients With Colorectal Cancer
RATIONALE: Genetic studies may help in understanding the genetic processes that cause some
types of cancer.
PURPOSE: Genetic trial to study certain genes of patients who have stage II or stage III
colon cancer.
types of cancer.
PURPOSE: Genetic trial to study certain genes of patients who have stage II or stage III
colon cancer.
OBJECTIVES:
- Determine the adverse prognostic significance of 8p allelic imbalance (AI) in patients
with colon cancer.
- Determine if patient prognosis is dependent on the region of 8p AI.
- Perform fine mapping studies to further localize the putative tumor suppressor gene(s)
on 8p.
- Perform multicolor FISH to examine the role that 8p loss and 8q gain play in the
prognosis of patients whose tumors exhibit 8p AI.
OUTLINE: Matched normal and tumor DNA is analyzed for 8p allelic imbalance with at least 8
markers: D8S262 and D8S1825 localized to 8p23, D8S254 and D8S261 at 8p22, D8S560 and D8S136
at 8p21, and D8S1820 and D8S283 at 8p12. Normal/tumor tissue pairs are used for fine mapping
studies.
- Determine the adverse prognostic significance of 8p allelic imbalance (AI) in patients
with colon cancer.
- Determine if patient prognosis is dependent on the region of 8p AI.
- Perform fine mapping studies to further localize the putative tumor suppressor gene(s)
on 8p.
- Perform multicolor FISH to examine the role that 8p loss and 8q gain play in the
prognosis of patients whose tumors exhibit 8p AI.
OUTLINE: Matched normal and tumor DNA is analyzed for 8p allelic imbalance with at least 8
markers: D8S262 and D8S1825 localized to 8p23, D8S254 and D8S261 at 8p22, D8S560 and D8S136
at 8p21, and D8S1820 and D8S283 at 8p12. Normal/tumor tissue pairs are used for fine mapping
studies.
DISEASE CHARACTERISTICS:
- Diagnosis of resectable stage II or III adenocarcinoma of the colon
- Participated in NCCTG-914653
- DNA extracted from both normal and tumor tissue
PATIENT CHARACTERISTICS:
Age
- Under 70
We found this trial at
2
sites
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