Diagnostic Study of Gene Alterations in Patients With Acute Myeloid Leukemia



Status:Completed
Conditions:Blood Cancer, Blood Cancer, Hematology, Leukemia
Therapuetic Areas:Hematology, Oncology
Healthy:No
Age Range:15 - Any
Updated:4/21/2016
Start Date:February 1999
End Date:June 2006

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Assessment of the Partial Tandem Duplication of ALL1 (MLL) in Patients With Acute Myeloid Leukemia- A CALGB Leukemia Tissue Bank Project

RATIONALE: Diagnostic procedures, such as genetic testing, may improve the ability to detect
acute myeloid leukemia and determine the extent of disease.

PURPOSE: Diagnostic study to try to detect changes in the genes of patients who have acute
myeloid leukemia.

OBJECTIVES:

- Determine the frequency of partial tandem duplication of ALL1 (MLL) in patients with
acute myeloid leukemia (AML).

- Determine the predictive value of partial tandem duplication of ALL1 to identify a
subset of AML patients who have a short duration of complete remission.

OUTLINE: All samples are obtained from specimens collected on CALGB-9665. No additional
blood or bone marrow samples are collected.

Samples are examined by Southern blot analysis for gene rearrangement at 11q23. Samples
showing evidence of ALL1 gene rearrangement are further analyzed by reverse transcription
PCR amplification and/or cytogenetic analysis to detect partial tandem duplication of ALL1.

DISEASE CHARACTERISTICS:

- Prior registration on protocol CALGB-9665

- Diagnosed with acute myeloid leukemia (AML)

- Treated on a CALGB AML treatment protocol

- Diagnostic bone marrow or blood specimen available

PATIENT CHARACTERISTICS:

Age:

- 15 and over
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Memphis, Tennessee 38103
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