Diagnostic Study of Gene Alterations in Patients With Acute Myeloid Leukemia
| Status: | Completed |
|---|---|
| Conditions: | Blood Cancer, Blood Cancer, Hematology, Leukemia |
| Therapuetic Areas: | Hematology, Oncology |
| Healthy: | No |
| Age Range: | 15 - Any |
| Updated: | 4/21/2016 |
| Start Date: | February 1999 |
| End Date: | June 2006 |
Assessment of the Partial Tandem Duplication of ALL1 (MLL) in Patients With Acute Myeloid Leukemia- A CALGB Leukemia Tissue Bank Project
RATIONALE: Diagnostic procedures, such as genetic testing, may improve the ability to detect
acute myeloid leukemia and determine the extent of disease.
PURPOSE: Diagnostic study to try to detect changes in the genes of patients who have acute
myeloid leukemia.
acute myeloid leukemia and determine the extent of disease.
PURPOSE: Diagnostic study to try to detect changes in the genes of patients who have acute
myeloid leukemia.
OBJECTIVES:
- Determine the frequency of partial tandem duplication of ALL1 (MLL) in patients with
acute myeloid leukemia (AML).
- Determine the predictive value of partial tandem duplication of ALL1 to identify a
subset of AML patients who have a short duration of complete remission.
OUTLINE: All samples are obtained from specimens collected on CALGB-9665. No additional
blood or bone marrow samples are collected.
Samples are examined by Southern blot analysis for gene rearrangement at 11q23. Samples
showing evidence of ALL1 gene rearrangement are further analyzed by reverse transcription
PCR amplification and/or cytogenetic analysis to detect partial tandem duplication of ALL1.
- Determine the frequency of partial tandem duplication of ALL1 (MLL) in patients with
acute myeloid leukemia (AML).
- Determine the predictive value of partial tandem duplication of ALL1 to identify a
subset of AML patients who have a short duration of complete remission.
OUTLINE: All samples are obtained from specimens collected on CALGB-9665. No additional
blood or bone marrow samples are collected.
Samples are examined by Southern blot analysis for gene rearrangement at 11q23. Samples
showing evidence of ALL1 gene rearrangement are further analyzed by reverse transcription
PCR amplification and/or cytogenetic analysis to detect partial tandem duplication of ALL1.
DISEASE CHARACTERISTICS:
- Prior registration on protocol CALGB-9665
- Diagnosed with acute myeloid leukemia (AML)
- Treated on a CALGB AML treatment protocol
- Diagnostic bone marrow or blood specimen available
PATIENT CHARACTERISTICS:
Age:
- 15 and over
We found this trial at
46
sites
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Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
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Duke Comprehensive Cancer Center Leading-edge cancer care and research have been a hallmark of Duke...
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200 Hawkins Drive
Iowa City, Iowa 52242
Iowa City, Iowa 52242
800-237-1225
Holden Comprehensive Cancer Center at University of Iowa Holden Comprehensive Cancer Center is dedicated to...
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CCOP - Mount Sinai Medical Center The Mount Sinai Community Clinical Oncology Program (MSCCOP) is...
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Rhode Island Hospital Founded in 1863, Rhode Island Hospital in Providence, RI, is a private,...
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Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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Univ of Nebraska Med Ctr A vital enterprise in the nation’s heartland, the University of...
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6900 Georgia Ave NW
Washington, District of Columbia 20307
Washington, District of Columbia 20307
(202) 782-6849
Walter Reed Army Medical Center The Walter Reed National Military Medical Center is one of...
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Medical Center Boulevard
Winston-Salem, North Carolina 27157
Winston-Salem, North Carolina 27157
336-716-2255
Comprehensive Cancer Center of Wake Forest University Our newly expanded Comprehensive Cancer Center is the...
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