University of North Carolina Alumni Heart Study
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Depression, Peripheral Vascular Disease, Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 3/30/2019 |
| Start Date: | May 1996 |
| End Date: | May 2026 |
To continue surveillance of the participants in the University of North Carolina Alumni Heart
Study, which tests the hypothesis that hostility and related psychosocial factors are
involved in the pathogenesis of coronary heart disease.
Study, which tests the hypothesis that hostility and related psychosocial factors are
involved in the pathogenesis of coronary heart disease.
BACKGROUND:
Prevention of coronary heart disease (CHD) will be enhanced by controlling hypertension,
reducing blood cholesterol, maintaining normal weight, increasing physical activity, reducing
smoking, and having a healthy diet. Understanding how to achieve these important public
health aims requires an understanding of the behavioral factors involved in prevention.
Behavioral risk factors remain the single most preventable cause of human illness and
suffering. The University of North Carolina Alumni Heart Study is ideally suited to explore
the associations between and among these important behavioral risk factors, and to understand
how personality, in particular individual differences in hostility and depression act to
determine individuals' risk factor behaviors, and to answer important questions about the
role of hostility and psychosocial factors in CHD risk during the middle years.
The University of North Carolina Alumni Heart Study (UNCAHS) is a prospective study of the
role of psychosocial factors, in particular hostility, in the development of coronary heart
disease. The target population is composed of persons who completed the Minnesota Multiphasic
Personality Inventory while attending the University of North Carolina in the mid-1960s.
DESIGN NARRATIVE:
Surveillance of the members of the UNC Alumni Heart Study continues for an additional
five-year period . Studies continue on how hostility and other psychosocial factors are
related to each other and how they contribute to coronary heart disease risk. Data are
analyzed in order to test hypotheses about the role of psychosocial factors in weight
parameters, dietary practices and the contribution of spouse hostility to coronary risk.
To better understand the dynamic interrelationships of psychosocial and behavioral risk
factors of the adult life span, the trajectories of hostility, depression, smoking, body
mass, exercise patterns, and alcohol consumption will be mapped using multiple assessments
from age 19 to age 60. It is predicted that a significant proportion of the change in risk
behavior will be due to trajectories of hostility and depression, operating singly and in
combination over time. Tests will be made of the prospective associations of hostility,
depression, and other psychosocial variables (e.g., social support and job strain) with
coronary events and mortality observed while the cohort is middle-aged. The scope of the
psychosocial variables will be broadened to examine individual differences in personality
over the life course and dietary practices at midlife in addition to the indicators noted
above. The effect of gender on the natural history of coronary disease and coronary risk
profiles in women will be examined by monitoring changes in menopausal status, and patterns
of hormone replacement therapy use among women during midlife and the associations of these
factors with the other risk indicators.
Prevention of coronary heart disease (CHD) will be enhanced by controlling hypertension,
reducing blood cholesterol, maintaining normal weight, increasing physical activity, reducing
smoking, and having a healthy diet. Understanding how to achieve these important public
health aims requires an understanding of the behavioral factors involved in prevention.
Behavioral risk factors remain the single most preventable cause of human illness and
suffering. The University of North Carolina Alumni Heart Study is ideally suited to explore
the associations between and among these important behavioral risk factors, and to understand
how personality, in particular individual differences in hostility and depression act to
determine individuals' risk factor behaviors, and to answer important questions about the
role of hostility and psychosocial factors in CHD risk during the middle years.
The University of North Carolina Alumni Heart Study (UNCAHS) is a prospective study of the
role of psychosocial factors, in particular hostility, in the development of coronary heart
disease. The target population is composed of persons who completed the Minnesota Multiphasic
Personality Inventory while attending the University of North Carolina in the mid-1960s.
DESIGN NARRATIVE:
Surveillance of the members of the UNC Alumni Heart Study continues for an additional
five-year period . Studies continue on how hostility and other psychosocial factors are
related to each other and how they contribute to coronary heart disease risk. Data are
analyzed in order to test hypotheses about the role of psychosocial factors in weight
parameters, dietary practices and the contribution of spouse hostility to coronary risk.
To better understand the dynamic interrelationships of psychosocial and behavioral risk
factors of the adult life span, the trajectories of hostility, depression, smoking, body
mass, exercise patterns, and alcohol consumption will be mapped using multiple assessments
from age 19 to age 60. It is predicted that a significant proportion of the change in risk
behavior will be due to trajectories of hostility and depression, operating singly and in
combination over time. Tests will be made of the prospective associations of hostility,
depression, and other psychosocial variables (e.g., social support and job strain) with
coronary events and mortality observed while the cohort is middle-aged. The scope of the
psychosocial variables will be broadened to examine individual differences in personality
over the life course and dietary practices at midlife in addition to the indicators noted
above. The effect of gender on the natural history of coronary disease and coronary risk
profiles in women will be examined by monitoring changes in menopausal status, and patterns
of hormone replacement therapy use among women during midlife and the associations of these
factors with the other risk indicators.
No eligibility criteria
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