Nefazodone in the Treatment of Cocaine Dependence and Depression - 4
| Status: | Completed |
|---|---|
| Conditions: | Psychiatric, Pulmonary |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 21 - 55 |
| Updated: | 4/21/2016 |
| Start Date: | February 1997 |
Efficacy of Nefazodone in Cocaine Dependent Subjects
The purpose of this study is the use of Nefazodone in the treatment of cocaine dependence
and depression comorbidity.
and depression comorbidity.
The objective of this study is to determine the safety and efficacy of nefazodone (Serzone )
in depressed cocaine dependent subjects. This is a hypothesis-testing study which will
explore whether cocaine usage will be reduced in the nefazodone treatment group compared to
a placebo control group.
in depressed cocaine dependent subjects. This is a hypothesis-testing study which will
explore whether cocaine usage will be reduced in the nefazodone treatment group compared to
a placebo control group.
Inclusion Criteria:
DSM-IV diagnosis of cocaine dependence, Depression score of 12 or above and history of
depression. Males and non-pregnant, non-nursing females 21-55 years of age.
Exclusion Criteria:
Axis I diagnosis other than substance use disorder, major depression, anxiety of dysthymic
disorder. Physiological dependence on alcohol. Significant medical or neurological
history. Abnormal UA, CBC or Chem 23 (LFT's may be up to 3 times normal). Enrollment in an
opiate-substitution treatment program within 45 days of enrollment in the present study.
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