Encouraging Calcium Absorption and Bone Formation During Early Puberty
| Status: | Completed |
|---|---|
| Conditions: | Osteoporosis, Osteoporosis, Endocrine |
| Therapuetic Areas: | Endocrinology, Rheumatology |
| Healthy: | No |
| Age Range: | 9 - 12 |
| Updated: | 4/21/2016 |
| Start Date: | May 2001 |
| End Date: | November 2006 |
Optimization of Calcium Absorption and Bone Formation During Early Puberty
Increasing bone mass during puberty can ultimately decrease the risk of developing
osteoporosis, which causes bones to weaken and break more easily later in life. The purpose
of this study is to compare calcium absorption and bone growth in boys and girls on diets
including either a nondigestible oligosaccharide (NDO) or simple sugar.
osteoporosis, which causes bones to weaken and break more easily later in life. The purpose
of this study is to compare calcium absorption and bone growth in boys and girls on diets
including either a nondigestible oligosaccharide (NDO) or simple sugar.
Rapid increases in bone mass occur during calcium absorption and bone calcium deposition
during puberty, and these increases can enhance peak bone mass and ultimately decrease the
lifetime risk of osteoporosis. However, dietary, hormonal, and genetic factors likely affect
increased bone mass. This study will examine if adding NDO to a pubertal diet allows more
absorption of calcium by the body, producing stronger bones. The study will also assess how
the hormones produced by the body during puberty affect bone growth and whether genetic
factors affect calcium absorption or bone growth.
This study will last 2 years. At study entry, baseline pubertal hormone levels and bone mass
will be assessed. Both a dual-energy X-ray absorptiometry (DEXA) scan and a calcium stable
kinetic study measuring calcium absorption will be performed. Participants will then be
randomly assigned to receive calcium fortified food with or without added NDO for 1 year.
Calcium absorption will be measured again at 2 months. After the first year, calcium
kinetic, hormonal, and DEXA studies will be performed and compared to baseline results. A
final DEXA scan will be performed at the end of 2 years.
during puberty, and these increases can enhance peak bone mass and ultimately decrease the
lifetime risk of osteoporosis. However, dietary, hormonal, and genetic factors likely affect
increased bone mass. This study will examine if adding NDO to a pubertal diet allows more
absorption of calcium by the body, producing stronger bones. The study will also assess how
the hormones produced by the body during puberty affect bone growth and whether genetic
factors affect calcium absorption or bone growth.
This study will last 2 years. At study entry, baseline pubertal hormone levels and bone mass
will be assessed. Both a dual-energy X-ray absorptiometry (DEXA) scan and a calcium stable
kinetic study measuring calcium absorption will be performed. Participants will then be
randomly assigned to receive calcium fortified food with or without added NDO for 1 year.
Calcium absorption will be measured again at 2 months. After the first year, calcium
kinetic, hormonal, and DEXA studies will be performed and compared to baseline results. A
final DEXA scan will be performed at the end of 2 years.
- Tanner Stage 2 or 3
- Girls must not have started menstruating
- In the 10th to 90th percentile in body mass index (BMI) for their age
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