Genetic Study of Young Patients With Colorectal Cancer
Status: | Completed |
---|---|
Conditions: | Colorectal Cancer, Cancer |
Therapuetic Areas: | Oncology |
Healthy: | No |
Age Range: | 18 - 49 |
Updated: | 4/21/2016 |
Start Date: | May 2002 |
End Date: | December 2004 |
A Prospective Study Of The Prognostic Significance Of Microsatellite Instability In Patients With Early Age-Of-Onset Colorectal Cancer
RATIONALE: Identifying gene mutations (microsatellite instability) may allow doctors to plan
effective treatment for patients who develop colorectal cancer at an early age.
PURPOSE: Genetic trial to determine the significance of gene mutations in helping predict
the outcome of treatment in patients who develop stage I, stage II, or stage III colorectal
cancer at an early age.
effective treatment for patients who develop colorectal cancer at an early age.
PURPOSE: Genetic trial to determine the significance of gene mutations in helping predict
the outcome of treatment in patients who develop stage I, stage II, or stage III colorectal
cancer at an early age.
OBJECTIVES:
- Evaluate the prognostic significance (e.g., overall survival) of microsatellite
instability (MSI) status in patients with early age-of-onset stage I-III colorectal
cancer, assuming the presence of a quantitative interaction between MSI status and
family history of cancer.
- Evaluate the development of metachronous neoplasms in this patient population.
- Evaluate the histologic features and genetic changes associated with hereditary
nonpolyposis colorectal cancer in this patient population.
OUTLINE: This is a multicenter study. Patients are stratified according to family history
using the Amsterdam II criteria for hereditary nonpolyposis colorectal cancer (positive vs
negative).
Patients undergo baseline colonoscopy before or within 6 months of initial curative
resection and then surveillance colonoscopy at 1, 3, and 5 years (+/- 6 months) after
resection. The number, size, location, histology, and method of removal of polyps are
documented at the time of colonoscopy. Patients also undergo microsatellite instability
(MSI) status testing and complete family history questionnaires at baseline.
The prognostic significance of family history and MSI status is evaluated. The individual
histologic features of the tumors are compared with the MSI status to determine their
predictive value. The histologic features are also correlated with outcome to determine
their prognostic significance.
Patients may be referred for genetic counseling.
A certificate of confidentiality protecting the identity of research participants in this
project has been issued by the National Cancer Institute.
- Evaluate the prognostic significance (e.g., overall survival) of microsatellite
instability (MSI) status in patients with early age-of-onset stage I-III colorectal
cancer, assuming the presence of a quantitative interaction between MSI status and
family history of cancer.
- Evaluate the development of metachronous neoplasms in this patient population.
- Evaluate the histologic features and genetic changes associated with hereditary
nonpolyposis colorectal cancer in this patient population.
OUTLINE: This is a multicenter study. Patients are stratified according to family history
using the Amsterdam II criteria for hereditary nonpolyposis colorectal cancer (positive vs
negative).
Patients undergo baseline colonoscopy before or within 6 months of initial curative
resection and then surveillance colonoscopy at 1, 3, and 5 years (+/- 6 months) after
resection. The number, size, location, histology, and method of removal of polyps are
documented at the time of colonoscopy. Patients also undergo microsatellite instability
(MSI) status testing and complete family history questionnaires at baseline.
The prognostic significance of family history and MSI status is evaluated. The individual
histologic features of the tumors are compared with the MSI status to determine their
predictive value. The histologic features are also correlated with outcome to determine
their prognostic significance.
Patients may be referred for genetic counseling.
A certificate of confidentiality protecting the identity of research participants in this
project has been issued by the National Cancer Institute.
DISEASE CHARACTERISTICS:
- Diagnosis of stage I-III adenocarcinoma of the colon or rectum
- Must have undergone an initial curative resection within the past year
- No colon or rectal cancer resection that does not allow for definitive T or N
staging
- No initial post-surgical surveillance colonoscopy prior to study entry
- Must have a pathology specimen, with representative normal and tumor tissues,
available for submission to the ACOSOG Central Specimen Bank prior to study entry
- No personal or family history of familial adenomatous polyposis
- No recurrent colorectal cancer
PATIENT CHARACTERISTICS:
Age
- 18 to 49 at first diagnosis
Other
- Must be willing to provide a family cancer history to the study team and continue
with follow-up colonoscopic surveillance
- No other malignancy within the past 5 years except completely resected cervical
cancer or nonmelanoma skin cancer
- No evidence of recurrence of other prior malignancy
PRIOR CONCURRENT THERAPY:
Radiotherapy
- No prior pelvic radiotherapy for rectal cancer
- No concurrent preoperative pelvic radiotherapy for rectal cancer
Surgery
- See Disease Characteristics
We found this trial at
72
sites
Allegheny General Hospital At Allegheny General Hospital, our physicians and healthcare staff have earned an...
Click here to add this to my saved trials
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
Click here to add this to my saved trials
1025 Morehead Medical Dr # 600
Charlotte, North Carolina 28204
Charlotte, North Carolina 28204
(704) 355-2884
Blumenthal Cancer Center at Carolinas Medical Center As our patients wage their personal wars against...
Click here to add this to my saved trials
675 N Saint Clair St # 21-100
Chicago, Illinois 60611
Chicago, Illinois 60611
(312) 695-1156
Robert H. Lurie Comprehensive Cancer Center at Northwestern University The cancer center was first established...
Click here to add this to my saved trials
Cleveland Clinic Taussig Cancer Center At Taussig Cancer Institute, more than 250 highly skilled doctors,...
Click here to add this to my saved trials
115 Business loop 70 w
Columbia, Missouri 65203
Columbia, Missouri 65203
(573) 882-2100
Ellis Fischel Cancer Center at University of Missouri - Columbia At Ellis Fischel Cancer Center,...
Click here to add this to my saved trials
Baylor University Medical Center Baylor University Medical Center in Dallas, TX is ranked nationally in...
Click here to add this to my saved trials
City of Hope Comprehensive Cancer Center City of Hope is a leading research and treatment...
Click here to add this to my saved trials
Duke Comprehensive Cancer Center Leading-edge cancer care and research have been a hallmark of Duke...
Click here to add this to my saved trials
Inova Fairfax Hospital Inova Fairfax Hospital, Inova's flagship hospital, is an 833-bed, nationally recognized regional...
Click here to add this to my saved trials
4725 North Federal Highway
Fort Lauderdale, Florida 33308
Fort Lauderdale, Florida 33308
(954) 492-5764
Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital Holy Cross Hospital's Michael...
Click here to add this to my saved trials
200 Hawkins Drive
Iowa City, Iowa 52242
Iowa City, Iowa 52242
800-237-1225
Holden Comprehensive Cancer Center at University of Iowa Holden Comprehensive Cancer Center is dedicated to...
Click here to add this to my saved trials
601 Elmwood Avenue
Rochester, New York 14642
Rochester, New York 14642
(585) 275-5830
James P. Wilmot Cancer Center at University of Rochester Medical Center The Wilmot Cancer Center...
Click here to add this to my saved trials
Click here to add this to my saved trials
12902 USF Magnolia Dr
Tampa, Florida 33612
Tampa, Florida 33612
(888) 663-3488
H. Lee Moffitt Cancer Center & Research Institute Moffitt Cancer Center in Tampa, Florida, has...
Click here to add this to my saved trials
Abington Memorial Hospital Abington Memorial Hospital (AMH) is a 665-bed, regional referral center and teaching...
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Rush - Copley Medical Center Rush-Copley is proud to be the leading provider of health...
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Presbyterian Hospital At Novant Health Presbyterian Medical Center, we are welcoming a new era in...
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
1221 Pleasant St
Des Moines, Iowa 50309
Des Moines, Iowa 50309
(515) 241-4141
John Stoddard Cancer Center at Iowa Methodist Medical Center Iowa's first children's cancer center opened...
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
1515 Holcombe Blvd
Houston, Texas 77030
Houston, Texas 77030
713-792-2121
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
Click here to add this to my saved trials
Click here to add this to my saved trials
Central Baptist Hospital Located in Lexington, Ky., Baptist Health Lexington offers some of the most...
Click here to add this to my saved trials
Click here to add this to my saved trials
2160 S. First Ave.
Maywood, Illinois 60153
Maywood, Illinois 60153
888-584-7888
Cardinal Bernardin Cancer Center at Loyola University Medical Center The Cardinal Bernardin Cancer Center is...
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
8800 W. Doyne Avenue
Milwaukee, Wisconsin 53226
Milwaukee, Wisconsin 53226
(414) 805-6840
Medical College of Wisconsin Cancer Center Cancer touches everyone in our community, and for many,...
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
1211 Medical Center Drive
Nashville, Tennessee 37232
Nashville, Tennessee 37232
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
3400 Civic Center Blvd
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
(215) 662-6065
Abramson Cancer Center of the University of Pennsylvania The Abramson Cancer Center of the University...
Click here to add this to my saved trials
111 S 11th St,
Philadelphia, Pennsylvania 19107
Philadelphia, Pennsylvania 19107
(877) 503-8350
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia The Kimmel Cancer Center at Jefferson...
Click here to add this to my saved trials
Click here to add this to my saved trials
Western Pennsylvania Hospital Featuring 308 private patient beds, West Penn Hospital has served Bloomfield and...
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Medical Center Boulevard
Winston-Salem, North Carolina 27157
Winston-Salem, North Carolina 27157
336-716-2255
Comprehensive Cancer Center of Wake Forest University Our newly expanded Comprehensive Cancer Center is the...
Click here to add this to my saved trials
Click here to add this to my saved trials