Study of Karenitecin (BNP1350) in Patients With Brain Tumors
| Status: | Completed |
|---|---|
| Conditions: | Brain Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/25/2018 |
| Start Date: | October 2001 |
Phase 2 Treatment of Adults With Primary Malignant Glioma With Karenitecin
The purpose of this study is to evaluate safety and efficacy ofKarenitecin (BNP1350) as a
treatment of adults with brain tumors.
treatment of adults with brain tumors.
- Confirmed diagnosis of a newly diagnosed glioblastoma multiforme or
recurrent/progressive glioblastoma multiforme, anaplastic astrocytoma, or anaplastic
oligodendroglioma.
- Evidence of measurable recurrent or residual primary CNS neoplasm.
- An interval of at least 3 weeks between prior surgical resection or 6 weeks between
prior radiotherapy or chemotherapy, and enrollment on this protocol unless there is
unequivocal evidence of tumor progression after surgery, radiotherapy, or
chemotherapy.
- Hematocrit > 29%, ANC > 1,500, platelets > 125,000
- Serum creatinine < 1.5 mg/dl, BUN < 25 mg/dl, serum SGOT and bilirubin < 1.5 times
upper limit of normal
- Negative pregnancy test for female patients
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