Treatment of Depression in Parkinson's Disease Trial
| Status: | Completed |
|---|---|
| Conditions: | Depression, Depression, Parkinsons Disease |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 35 - 80 |
| Updated: | 4/21/2016 |
| Start Date: | June 2003 |
| End Date: | January 2009 |
Treatment of Depression in Patients With Parkinson's Disease
The goal of this study is to evaluate the effectiveness and safety of two
antidepressants--nortriptyline and paroxetine, compared to placebo in patients with
Parkinson's disease and depression.
antidepressants--nortriptyline and paroxetine, compared to placebo in patients with
Parkinson's disease and depression.
Depression is the most common neuropsychiatric disorder found in patients with Parkinson's
disease (PD). It causes immense personal suffering and is associated with increased
disability and caregiver burden.
Despite the adverse consequences of depression in patients with PD, there are virtually no
empirical data to guide clinical treatment. This study will begin to answer some questions
on the treatment of depression by testing a SSRI (selective serotonin reuptake inhibitor)
antidepressant, paroxetine, a tricyclic antidepressant, nortriptyline, and placebo in a
placebo-controlled trial.
A total of 75 patients with PD will be randomized to each of the three arms in a balanced
design.
disease (PD). It causes immense personal suffering and is associated with increased
disability and caregiver burden.
Despite the adverse consequences of depression in patients with PD, there are virtually no
empirical data to guide clinical treatment. This study will begin to answer some questions
on the treatment of depression by testing a SSRI (selective serotonin reuptake inhibitor)
antidepressant, paroxetine, a tricyclic antidepressant, nortriptyline, and placebo in a
placebo-controlled trial.
A total of 75 patients with PD will be randomized to each of the three arms in a balanced
design.
inclusion criteria:
- Parkinson's disease without dementia.
- Depression.
- Males or females.
exclusion criteria:
- Psychosis
- Heart block
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