Hepatic Arterial Infusion With Floxuridine and Systemic Irinotecan After Surgery in Treating Patients With Hepatic (Liver) Metastases From Colorectal Cancer

OBJECTIVES:

- Determine the toxicity of hepatic arterial infusion with floxuridine and systemic
irinotecan adjuvant to liver metastases resection or ablation with or without resection
in patients with hepatic metastases secondary to colorectal cancer.

- Determine the overall survival of patients treated with this regimen.

- Determine the time to any hepatic recurrence or progression in patients treated with
this regimen.

OUTLINE: This is a multicenter study. Patients are stratified according to prior therapy
(liver metastases resection only vs ablation with or without resection).

Within 4-8 weeks after prior resection or ablation, patients receive hepatic arterial
infusion of floxuridine continuously on days 1-14 and irinotecan IV over 30 minutes on days
1 and 15. Treatment repeats every 28 days for 6 courses in the absence of unacceptable
toxicity.

Patients are followed every 3 months for 2 years.

DISEASE CHARACTERISTICS:

- Histologically confirmed metastatic colorectal adenocarcinoma

- Primary colorectal adenocarcinoma that has been completely resected (R0 disease)

- No evidence of residual, viable tumor by abdominal/pelvic helical CT scan
or MRI with IV contrast

- Metastatic disease

- No more than 9 liver metastases

- All lesions completely resected or completely treated by ablation (with or
without resection)

- All lesions treated by ablation must have been less than 5 cm in size
and at least 5 mm away from main/left/right portal vein, common bile
duct, and inferior vena cava

- All resected lesions must have a negative surgical margin (R0)

- Disease progression after prior systemic irinotecan for metastatic disease allowed

- No extrahepatic metastases confirmed by chest CT scan except colorectal mesenteric
lymph node metastases resected at the time of primary tumor resection

- No other prior resection of extrahepatic metastases

- Must have the entire liver remnant perfused with a single catheter

- Must have a nuclear medicine macro-aggregated albumin flow scan to confirm the area
of pump perfusion before study registration

PATIENT CHARACTERISTICS:

Age

- 18 and over

Performance status

- ECOG 0-2 OR

- Zubrod 0-2

Life expectancy

- Not specified

Hematopoietic

- WBC at least 3,000/mm^3

- Absolute granulocyte count at least 1,500/mm^3

- Absolute neutrophil count at least 1,500/mm^3

- Platelet count at least 100,000/mm^3

Hepatic

- Bilirubin no greater than 2 mg/dL

- Alkaline phosphatase no greater than 2.0 times upper limit of normal (ULN)

- AST and ALT no greater than 2.0 times ULN

- No active hepatitis B or C infection

- No histological evidence of cirrhosis

Renal

- Creatinine no greater than 1.5 times ULN

- Calcium less than 1.3 times ULN

Other

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception

- Postmenopausal women must be amenorrheic for at least 12 consecutive months to
be deemed not fertile

- Medically fit to begin chemotherapy between 4 and 8 weeks after surgery

- Prior cancer allowed if all of the following criteria are met:

- Undergone potentially curative therapy for all prior malignancies

- No other malignancy within the past 5 years except the following:

- Effectively treated basal cell or squamous cell skin cancer

- Carcinoma in situ of the cervix that has been effectively treated by
surgery alone

- Lobular carcinoma in situ of the ipsilateral or contralateral breast
treated by surgery alone

- No evidence of recurrence of any prior malignancy

- No prior hepatic arterial infusion pump malfunction, malperfusion, or infection

PRIOR CONCURRENT THERAPY:

Biologic therapy

- No concurrent immunologic or biologic therapy

Chemotherapy

- No prior chemotherapy within 4 weeks before hepatic resection or hepatic ablation
(with or without resection)

- No prior hepatic arterial infusion with fluorouracil or floxuridine

Radiotherapy

- No concurrent adjuvant radiotherapy to the pelvis

- No other concurrent radiotherapy

Other

- No other concurrent systemic therapy