Cognitive and Neurophysiological Effects of Raloxifene in Alzheimer's Disease

The aim of this study is to determine the effectiveness of treatment with raloxifene, an
estrogen-like medication (classified as Selective Estrogen Receptor Modulators (SER's))
approved by the Food and Drug Administration for the treatment of osteoporosis, in improving
memory and the ability to live independently in postmenopausal women with Alzheimer's
disease. Patients who volunteer for this study will need to visit the clinic 7 times
(participate) over a period of five months and will receive either raloxifene or a harmless,
inactive pill called a placebo. Neither the volunteers nor the study staff will know which
type of pill a patient receives. Patients must be generally healthy and have
mild-to-moderate dementia. There must be a patient caregiver who can watch for side effects
and ensure that the patient takes the study pills on schedule over a period of three months.

Patients will undergo neuropsychological tests and an evaluation of the ability to live
independently at each visit as well as laboratory evaluations, such as the taking of blood.
Each visit will last approximately 3 hours. A total of 20 patients is being recruited to
participate in this study at the University of Wisconsin.

Inclusion Criteria:

- Postmenopausal women with Alzheimer's disease and without other dementias (diagnosed
by study staff or from an outside clinic)

- Mini Mental Status Exam score greater than 15/30

Exclusion Criteria:

- History of deep vein thrombosis or blot clots

- Diabetes

- Active heart disease or stroke

- Liver problems including hepatitis

- Severe vision or hearing problems

- Tobacco use