Registry for African Americans With Early Rheumatoid Arthritis

RA is an autoimmune disease in which the body's immune system attacks its own tissues. It
occurs in all races and ethnic groups and affects about two to three times as many women as
men. Variations in certain genes that play a role in the immune system are associated with a
tendency to develop RA. Some individuals without these genetic variations may develop this
disease, while others who possess the variations never develop RA. Scientists believe that
some environmental factors may play a part in triggering the disease process in people whose
genetic makeup makes them susceptible to RA. This registry of African Americans with early
RA will provide clinical and x-ray data and DNA to help scientists analyze genetic and
nongenetic factors that might predict disease course and outcomes of RA in this population.

Participants in this registry will be enrolled in the study until they reach 5 years in
their disease duration. For example, if a participant enters the study after 1 year of
having RA, he or she will continue for 4 years. Participants will have three office visits
(screening, 3 years' disease duration, and 5 years' disease duration) at which they will
complete questionnaires and have blood samples taken, x-rays of their hands and feet, and
DEXA scans. Between office visits, the study coordinator will call participants every 6
months to update any changes in medications or health problems.

Inclusion Criteria

- African American

- Rheumatoid arthritis for less than 2 years