Proteomic Profiling in Diagnosing Non-Small Cell Lung Cancer in Patients Who Are Undergoing Lung Resection for Suspicious Stage I Lung Lesions

OBJECTIVES:

Primary

- Determine, prospectively, whether serum proteomic profiling can predict the presence of
primary non-small cell lung cancer in patients with clinically suspicious stage I lung
lesions who are undergoing lung resection.

Secondary

- Correlate the serum proteomic profile with pathologic nodal status and histopathologic
features of primary lung cancer in these patients.

- Correlate the initial and follow-up serum proteomic profile with overall and
cancer-specific survival of these patients.

- Correlate changes in the proteomic profile (preoperative to postoperative) with overall
and cancer-specific survival of these patients.

Tertiary

- Determine whether novel molecular strategies can predict the presence of lung cancer
and/or the biologic behavior of an individual cancer in these patients.

Inclusion Criteria:

1. Patient must be ≥18 years of age.

2. Patient must have a clinically suspicious stage I (cT1-2 N0 M0) lung lesion.

3. Patient must have pre-operative imaging procedures within 60 days prior to the date
of the lung resection: Helical CT scan of the chest and CT scan of the upper abdomen,
including the liver and adrenal glands (with or without IV contrast), as clinically
indicated. The helical CT must rule out metastatic disease in the liver and adrenal
glands.

4. Patient, or the patient's legally acceptable representative, must provide a signed
and dated written informed consent PRIOR to registration and any study-related
procedures being performed.

5. Patient must provide written authorization to allow the use and disclosure of their
protected health information. NOTE: This may be obtained in either the study-specific
informed consent or in a separate authorization form and must be obtained from the
patient PRIOR to registration and any study-related procedures being performed.

6. If patient is a survivor of a prior cancer, the following criteria are met:

1. Patient has undergone potentially curative therapy for all prior malignancies,

2. No evidence of any prior malignancies for at least 5 years with no evidence of
recurrence (except for effectively treated basal cell or squamous carcinoma of
the skin, carcinoma in-situ of the cervix that has been effectively treated by
surgery alone, or lobular carcinoma in-situ of the ipsilateral or contralateral
breast treated by surgery alone),

3. Patient is deemed by their treating physician to be at low risk for recurrence
from prior malignancies.

Exclusion Criteria:

1. Patient has undergone previous lung resection within the preceding 30 days.

2. Patient has received prior chemotherapy or radiotherapy.

3. Patient has had a blood product transfusion of any kind within the past 60 days of
the operative procedure.