Gender, Obesity, C-Reactive Protein, and Oxidative Stress



Status:Completed
Conditions:Peripheral Vascular Disease
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:9/29/2017
Start Date:April 2004
End Date:March 24, 2008

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Trial Summary
Trial Overview
Inclusion Criteria
This randomized placebo-controlled trial will test whether supplementing with vitamins C and
E can lower markers of inflammation and oxidative stress in healthy adults. We will examine
whether one antioxidant vitamin is more effective than another, and whether gender or body
fat influence the treatment effects. We will also determine whether gender, body fat, or
menopausal status are associated with baseline concentrations of inflammation and oxidative
stress markers.

Participants will be given 1000 mg vitamin C or 800 IU vitamin E daily for 60 days.

Inclusion criteria:

- Nonsmoker and not passively exposed

- Males and females 18 year and older

- Able to take vitamin supplements

- Able to take acetominophen instead of aspirin or NSAIDs during the study

Exclusion criteria:

- Pregnancy or lactation

- History of ever smoking or passive smoke exposure in the last year

- Active liver disease; history of HIV/AIDS, diabetes, kidney stones, hemochromatosis,
or autoimmune diseases; heart disease, stroke, or cancer in the last 5 years

- User of prescribed anti-inflammatory or lipid-lowering medications, oral
contraceptives, hormone replacement therapy, or blood-thinning drugs

- User of iron supplements or vitamin E at 600 IU per day or more

- Consumption of more than 2 alcoholic beverages per day
We found this trial at
1
site
University of California, Berkeley School of Public Health
Berkeley, California 94720
?
mi
from
Berkeley, CA
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