Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell Tumor
Status: | Completed |
---|---|
Conditions: | Brain Cancer, Brain Cancer |
Therapuetic Areas: | Oncology |
Healthy: | No |
Age Range: | 3 - 25 |
Updated: | 9/9/2018 |
Start Date: | January 2007 |
End Date: | May 2009 |
Radiotherapy Alone Versus Chemotherapy Followed By Response-Based Radiotherapy For Newly Diagnosed Primary CNS Germinoma
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in
chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or
die. It is not yet known whether radiation therapy alone is as effective as chemotherapy plus
radiation therapy in treating germ cell tumor.
PURPOSE: This randomized phase III trial is studying radiation therapy alone to see how well
it works compared to chemotherapy and radiation therapy in treating patients with newly
diagnosed primary CNS germ cell tumor.
chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or
die. It is not yet known whether radiation therapy alone is as effective as chemotherapy plus
radiation therapy in treating germ cell tumor.
PURPOSE: This randomized phase III trial is studying radiation therapy alone to see how well
it works compared to chemotherapy and radiation therapy in treating patients with newly
diagnosed primary CNS germ cell tumor.
OBJECTIVES:
Primary
- Compare event-free survival and overall survival of patients with newly diagnosed
primary CNS germ cell tumor treated with conventional radiotherapy alone (regimen A) vs
chemotherapy followed by tumor response-based radiotherapy (regimen B).
Secondary
- Determine the complete response rate in patients treated with regimen B.
- Determine the acute and subacute toxicity of regimen B in these patients.
- Compare treatment-related morbidity, in terms of verbal learning and memory, executive
functioning, and quality of life, in patients treated with these regimens.
- Determine the prognostic value of baseline serum, lumbar, and intraventricular levels of
human chorionic gonadotropin levels from patients treated with these regimens.
- Determine the prognostic value of extent of disease (M+ vs modified M+ vs M0) on
event-free survival and overall survival of patients treated with these regimens.
OUTLINE: This is a randomized, multicenter study. Patients are stratified according to tumor
location (pineal vs suprasellar vs pineal + suprasellar or other), and disease stage
(disseminated vs occult multi-focal vs localized). Patients are randomized to 1 of 2
treatment regimens.
All patients undergo an operative procedure (endoscopic biopsy, stereotactic biopsy, or open
craniotomy) to confirm the diagnosis of pure germ cell germinoma followed by an
intraoperative and perioperative staging evaluation.
- Regimen A (radiotherapy only): Within 52 days of surgery, patients undergo standard-dose
radiotherapy once daily on days 1-5 for approximately 5-6 weeks.
- Regimen B (chemotherapy plus radiotherapy):
- Courses 1 and 2: Patients receive carboplatin IV over 1 hour on days 1 and 2 and
etoposide IV over 2 hours on days 1-3. Treatment repeats every 21 days for 2
courses.
Patients achieving a complete response (CR) proceed to reduced-dose radiotherapy. Patients
with minimal residual disease (MRD), a partial response (PR), or stable disease (SD) receive
chemotherapy courses 3 and 4 as outlined below. Patients with progressive disease undergo a
second surgical procedure for biopsy and are restaged. Patients with a confirmed diagnosis of
germ cell tumor with no change in tumor markers and no new lesions after restaging proceed to
chemotherapy courses 3 and 4.
- Courses 3 and 4: Patients receive cisplatin IV over 6 hours on day 1, cyclophosphamide
IV over 1 hour on days 2 and 3, and filgrastim (G-CSF) subcutaneously or IV beginning on
day 4 and continuing until blood counts recover. Treatment repeats every 21 days for 2
courses.
Patients achieving a CR or MRD proceed to reduced-dose radiotherapy. Patients with a PR, SD,
or progressive disease are restaged. Patients with a confirmed diagnosis of germ cell tumor
after restaging undergo standard radiotherapy as in regimen A.
- Reduced-dose radiotherapy: Within 6 weeks of starting course 4, patients undergo
lower-dose radiotherapy once daily on days 1-5 for 5 weeks.
Treatment in both regimens continues in the absence of unacceptable toxicity or in the event
that a non-germinomatous germ cell tumor is detected.
Quality of life and neuropsychological function within the domains of intelligence,
attention-concentration, memory, and executive functioning are assessed at 9, 30, and 60
months after diagnosis.
Patients are followed every 4 months for 2 years, and then annually thereafter.
PROJECTED ACCRUAL: A total of 225 patients (approximately 112 per treatment regimen) will be
accrued for this study within 5 years.
Primary
- Compare event-free survival and overall survival of patients with newly diagnosed
primary CNS germ cell tumor treated with conventional radiotherapy alone (regimen A) vs
chemotherapy followed by tumor response-based radiotherapy (regimen B).
Secondary
- Determine the complete response rate in patients treated with regimen B.
- Determine the acute and subacute toxicity of regimen B in these patients.
- Compare treatment-related morbidity, in terms of verbal learning and memory, executive
functioning, and quality of life, in patients treated with these regimens.
- Determine the prognostic value of baseline serum, lumbar, and intraventricular levels of
human chorionic gonadotropin levels from patients treated with these regimens.
- Determine the prognostic value of extent of disease (M+ vs modified M+ vs M0) on
event-free survival and overall survival of patients treated with these regimens.
OUTLINE: This is a randomized, multicenter study. Patients are stratified according to tumor
location (pineal vs suprasellar vs pineal + suprasellar or other), and disease stage
(disseminated vs occult multi-focal vs localized). Patients are randomized to 1 of 2
treatment regimens.
All patients undergo an operative procedure (endoscopic biopsy, stereotactic biopsy, or open
craniotomy) to confirm the diagnosis of pure germ cell germinoma followed by an
intraoperative and perioperative staging evaluation.
- Regimen A (radiotherapy only): Within 52 days of surgery, patients undergo standard-dose
radiotherapy once daily on days 1-5 for approximately 5-6 weeks.
- Regimen B (chemotherapy plus radiotherapy):
- Courses 1 and 2: Patients receive carboplatin IV over 1 hour on days 1 and 2 and
etoposide IV over 2 hours on days 1-3. Treatment repeats every 21 days for 2
courses.
Patients achieving a complete response (CR) proceed to reduced-dose radiotherapy. Patients
with minimal residual disease (MRD), a partial response (PR), or stable disease (SD) receive
chemotherapy courses 3 and 4 as outlined below. Patients with progressive disease undergo a
second surgical procedure for biopsy and are restaged. Patients with a confirmed diagnosis of
germ cell tumor with no change in tumor markers and no new lesions after restaging proceed to
chemotherapy courses 3 and 4.
- Courses 3 and 4: Patients receive cisplatin IV over 6 hours on day 1, cyclophosphamide
IV over 1 hour on days 2 and 3, and filgrastim (G-CSF) subcutaneously or IV beginning on
day 4 and continuing until blood counts recover. Treatment repeats every 21 days for 2
courses.
Patients achieving a CR or MRD proceed to reduced-dose radiotherapy. Patients with a PR, SD,
or progressive disease are restaged. Patients with a confirmed diagnosis of germ cell tumor
after restaging undergo standard radiotherapy as in regimen A.
- Reduced-dose radiotherapy: Within 6 weeks of starting course 4, patients undergo
lower-dose radiotherapy once daily on days 1-5 for 5 weeks.
Treatment in both regimens continues in the absence of unacceptable toxicity or in the event
that a non-germinomatous germ cell tumor is detected.
Quality of life and neuropsychological function within the domains of intelligence,
attention-concentration, memory, and executive functioning are assessed at 9, 30, and 60
months after diagnosis.
Patients are followed every 4 months for 2 years, and then annually thereafter.
PROJECTED ACCRUAL: A total of 225 patients (approximately 112 per treatment regimen) will be
accrued for this study within 5 years.
DISEASE CHARACTERISTICS:
- Histologically confirmed primary CNS pure germ cell tumor
- Diagnosed within the past 31 days
- Meets any 1 OR none (i.e., M0 [localized disease]) of the following staging criteria:
- M+ (disseminated disease)
- Leptomeningeal or intraventricular metastases visualized on MRI scans of the
brain and spine
- Clumps of tumor cells on lumbar cerebrospinal fluid (CSF) cytology
- Visible tumor studding the walls of the lateral or third ventricles noted
during endoscopy or surgery
- Primary tumor arising within the parenchyma of the brain, brainstem, or
spinal cord
- Measurable multi-focal tumors arising in both the pineal and suprasellar
regions (i.e., multiple midline tumors)
- Infiltrative, intra-axial extension on brain MRI > 1 cm beyond enhancing
tumor
- Modified M+ (occult multi-focal disease)
- M0 at diagnosis with a localized pineal region tumor with signs and symptoms
of diabetes insipidus without measurable disease in the suprasellar region
- Lumbar CSF assay meeting criteria for the following marker profiles:
- Serum and CSF beta human chorionic gonadotropin (β-HCG) ≤ 50 IU/dL
- Serum alpha fetoprotein (AFP) ≤ 10 IU/L AND ≤ institutional norm
- CSF AFP ≤ 2.0 IU/L AND ≤ institutional norm
PATIENT CHARACTERISTICS:
Age
- 3 to 25
Performance status
- Not specified
Life expectancy
- Not specified
Hematopoietic
- Absolute neutrophil count > 1,000/mm^3
- Platelet count > 100,000/mm^3 (transfusion independent)
- Hemoglobin > 10.0 g/dL (transfusion allowed)
Hepatic
- Bilirubin ≤ 1.5 times upper limit of normal (ULN)
- aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 2.5 times ULN
Renal
- Creatinine adjusted according to age as follows*:
- No greater than 0.4 mg/dL (≤ 5 months)
- No greater than 0.5 mg/dL (6 months -11 months)
- No greater than 0.6 mg/dL (1 year-23 months)
- No greater than 0.8 mg/dL (2 years-5 years)
- No greater than 1.0 mg/dL (6 years-9 years)
- No greater than 1.2 mg/dL (10 years-12 years)
- No greater than 1.4 mg/dL (13 years and over [female])
- No greater than 1.5 mg/dL (13 years to 15 years [male])
- No greater than 1.7 mg/dL (16 years and over [male]) AND
- Creatinine clearance OR radioisotope glomerular filtration rate > 70 mL/min
Other
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- Euthyroid (with or without levothyroxine sodium therapy) as determined by normal T4 ±
thyroid-stimulating hormone levels*
- Diabetes insipidus allowed provided patient is relatively stable on desmopressin
acetate
- Normal endogenous cortisol function*
- Adequate antidiuretic hormone reserves* NOTE: *Unless receiving replacement therapy
PRIOR CONCURRENT THERAPY:
Biologic therapy
- Not specified
Chemotherapy
- Not specified
Endocrine therapy
- Concurrent replacement hormones allowed (e.g., corticosteroids, levothyroxine sodium,
and desmopressin acetate)
Radiotherapy
- Not specified
Surgery
- Prior surgery for germ cell tumor allowed
Other
- No other prior therapy for germ cell tumor
- Concurrent anticonvulsants allowed
We found this trial at
96
sites
7720 South Broadway #110
Aurora, Colorado 80045
Aurora, Colorado 80045
Click here to add this to my saved trials

Akron Children's Hospital From humble beginnings as a day nursery in 1890, Akron Children
Click here to add this to my saved trials

1201 Camino de Salud Northeast
Albuquerque, New Mexico 87131
Albuquerque, New Mexico 87131
(505) 272-4946

University of New Mexico Cancer Center It’s been 40 years since the New Mexico State...
Click here to add this to my saved trials

4900 Mueller Boulevard
Austin, Texas 78723
Austin, Texas 78723
(512) 324-0000

Dell Children's Medical Center of Central Texas Welcome to Dell Children
Click here to add this to my saved trials

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins The name Johns Hopkins has become synonymous...
Click here to add this to my saved trials

417 State St #30
Bangor, Maine 04401
Bangor, Maine 04401
(207) 973-7478

CancerCare of Maine at Eastern Maine Medical Center Our compassionate, experienced physicians specialize in the...
Click here to add this to my saved trials

Click here to add this to my saved trials

1300 Morris Park Avenue
Bronx, New York 10461
Bronx, New York 10461
718.430.2302

Albert Einstein Cancer Center at Albert Einstein College of Medicine The Albert Einstein Cancer Center...
Click here to add this to my saved trials

Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
Click here to add this to my saved trials

86 Jonathan Lucas Street
Charleston, South Carolina 29425
Charleston, South Carolina 29425
(843) 792-0700

Hollings Cancer Center at Medical University of South Carolina Located at the Medical University of...
Click here to add this to my saved trials

1025 Morehead Medical Dr # 600
Charlotte, North Carolina 28204
Charlotte, North Carolina 28204
(704) 355-2884

Blumenthal Cancer Center at Carolinas Medical Center As our patients wage their personal wars against...
Click here to add this to my saved trials

3333 Burnet Avenue # Mlc3008
Cincinnati, Ohio 45229
Cincinnati, Ohio 45229
1-513-636-4200

Cincinnati Children's Hospital Medical Center Patients and families from across the region and around the...
Click here to add this to my saved trials

Cleveland Clinic Taussig Cancer Center At Taussig Cancer Institute, more than 250 highly skilled doctors,...
Click here to add this to my saved trials

Rainbow Babies and Children's Hospital UH Rainbow Babies & Children’s Hospital is a 244-bed, full-service...
Click here to add this to my saved trials

115 Business loop 70 w
Columbia, Missouri 65203
Columbia, Missouri 65203
(573) 882-2100

Ellis Fischel Cancer Center at University of Missouri - Columbia At Ellis Fischel Cancer Center,...
Click here to add this to my saved trials

3209 Colonial Drive
Columbia, South Carolina 29203
Columbia, South Carolina 29203
(803) 296-3000

Palmetto Health South Carolina Cancer Center The Palmetto Health Cancer Centers located in Columbia, South...
Click here to add this to my saved trials

Driscoll Children's Hospital Driscoll Children's Hospital was built because Clara Driscoll's will requested that a...
Click here to add this to my saved trials

2201 Inwood Rd
Dallas, Texas 75235
Dallas, Texas 75235
(214) 645-8300

Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas From its...
Click here to add this to my saved trials

Barbara Ann Karmanos Cancer Institute Karmanos is based in southeast Michigan, in midtown Detroit, and...
Click here to add this to my saved trials

2776 Cleveland Ave
Fort Myers, Florida 33905
Fort Myers, Florida 33905
(239) 343-9500

Lee Cancer Care of Lee Memorial Health System Our origins can be traced to the...
Click here to add this to my saved trials

Greenville Hospital Cancer Center Greenville Health System (GHS) is a public not-for-profit academic healthcare delivery...
Click here to add this to my saved trials

University of Mississippi Cancer Clinic he Cancer Institute is home to the ACT Tobacco Treatment,...
Click here to add this to my saved trials

Nemours Children's Clinic At Nemours Children’s Clinic, Jacksonville, we've treated every child as we would...
Click here to add this to my saved trials

Children's Mercy Hospital Children's Mercy Hospitals and Clinics continues redefining pediatric medicine throughout the Midwest...
Click here to add this to my saved trials

800 Rose St
Lexington, Kentucky 40536
Lexington, Kentucky 40536
(859) 257-4488

Lucille P. Markey Cancer Center at University of Kentucky The Markey Cancer Center was founded...
Click here to add this to my saved trials

11234 Anderson Street
Loma Linda, California 92354
Loma Linda, California 92354
(909) 558-4126

Loma Linda University Cancer Institute at Loma Linda University Medical Center Loma Linda University Cancer...
Click here to add this to my saved trials

701 E 28th St # 202
Long Beach, California 90806
Long Beach, California 90806
(562) 933-8600

Jonathan Jaques Children's Cancer Center at Miller Children's Hospital JCCC has comprehensive psychosocial programs and...
Click here to add this to my saved trials

Kosair Children's Hospital For more than a century, Kosair Children's Hospital and its predecessor hospitals...
Click here to add this to my saved trials

9300 Valley Children's Pl
Madera, California 93720
Madera, California 93720
(559) 353-3000

Children's Hospital Central California The Children's Hospital Central California is a not-for-profit, state-of-the-art children’s hospital...
Click here to add this to my saved trials

St. Jude Children's Research Hospital St. Jude is unlike any other pediatric treatment and research...
Click here to add this to my saved trials

Miami Children's Hospital Welcome to Miami Children
Click here to add this to my saved trials

701 West 168th Street
New York, New York 10032
New York, New York 10032
(212) 851-4680

Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center The Herbert Irving Comprehensive Cancer...
Click here to add this to my saved trials

800 NE 10th Street
Oklahoma City, Oklahoma 73104
Oklahoma City, Oklahoma 73104
(855) 750-2273

Oklahoma University Cancer Institute The Peggy and Charles Stephenson Cancer Center is located on the...
Click here to add this to my saved trials

2501 N Orange Ave # 235
Orlando, Florida 32804
Orlando, Florida 32804
(407) 303-1700

Florida Hospital Cancer Institute at Florida Hospital Orlando FHCI is the largest cancer center in...
Click here to add this to my saved trials

Click here to add this to my saved trials

Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...
Click here to add this to my saved trials

Click here to add this to my saved trials

593 Eddy Street
Providence, Rhode Island 02903
Providence, Rhode Island 02903
401-444-4000

Rhode Island Hospital Comprehensive Cancer Center The Comprehensive Cancer Center at Rhode Island Hospital is...
Click here to add this to my saved trials

601 Elmwood Avenue
Rochester, New York 14642
Rochester, New York 14642
(585) 275-5830

James P. Wilmot Cancer Center at University of Rochester Medical Center The Wilmot Cancer Center...
Click here to add this to my saved trials

Click here to add this to my saved trials

7700 Floyd Curl Dr
San Antonio, Texas 78229
San Antonio, Texas 78229
(210) 575-7000

Methodist Children's Hospital of South Texas Methodist Children
Click here to add this to my saved trials

4502 Medical Drive
San Antonio, Texas 78284
San Antonio, Texas 78284
(210) 567-7000

University of Texas Health Science Center at San Antonio The University of Texas Health Science...
Click here to add this to my saved trials

3001 W Dr Martin L King Jr
Tampa, Florida 33607
Tampa, Florida 33607
(813) 870-4123

St. Joseph's Cancer Institute at St. Joseph's Hospital St. Joseph's Hospital is known for its...
Click here to add this to my saved trials

Alfred I. duPont Hospital for Children Nemours began more than 70 years ago with the...
Click here to add this to my saved trials

1415 Tulane Ave., HC-62
Alexandria, Louisiana 70112
Alexandria, Louisiana 70112
504-988-6121

Tulane Cancer Center Office of Clinical Research As an academic cancer center, Tulane offers our...
Click here to add this to my saved trials

Click here to add this to my saved trials

Click here to add this to my saved trials

1365 Clifton Rd NE
Atlanta, Georgia 30322
Atlanta, Georgia 30322
(404) 778-1900

Winship Cancer Institute at Emory University Winship Cancer Institute of Emory University is Georgia
Click here to add this to my saved trials

Birmingham, Alabama 35294
Click here to add this to my saved trials

Click here to add this to my saved trials

Click here to add this to my saved trials

Click here to add this to my saved trials

Click here to add this to my saved trials

101 Manning Drive
Chapel Hill, North Carolina 27514
Chapel Hill, North Carolina 27514
(919) 966-0000

Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill One of the...
Click here to add this to my saved trials

3110 MacCorkle Ave. S.E.
Charleston, West Virginia 25304
Charleston, West Virginia 25304
304-347-1206

West Virginia University Health Sciences Center - Charleston The West Virginia University Robert C. Byrd...
Click here to add this to my saved trials

Children's Memorial Hospital, Chicago Ann & Robert H. Lurie Children
Click here to add this to my saved trials

Click here to add this to my saved trials

Click here to add this to my saved trials

4760 Sunset Blvd
Downey, California 90027
Downey, California 90027
(323) 783-6151

Southern California Permanente Medical Group We
Click here to add this to my saved trials

Farmington, Connecticut 06360
Click here to add this to my saved trials

Click here to add this to my saved trials

Click here to add this to my saved trials

Click here to add this to my saved trials

Click here to add this to my saved trials

Baylor University Medical Center - Houston Baylor University Medical Center in Dallas began in 1903...
Click here to add this to my saved trials

Click here to add this to my saved trials

East Tennessee Children's Hospital East Tennessee Children's Hospital is a not-for-profit, private, independent pediatric medical...
Click here to add this to my saved trials

Click here to add this to my saved trials

4018 W Capitol Ave.
Little Rock, Arkansas 72205
Little Rock, Arkansas 72205
(501) 296-1200

Arkansas Cancer Research Center at University of Arkansas for Medical Sciences The Winthrop P. Rockefeller...
Click here to add this to my saved trials

8700 Beverly Blvd.
Los Angeles, California 90048
Los Angeles, California 90048
1-800-233-2771

Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center Cedars-Sinai's Samuel Oschin Comprehensive Cancer Institute...
Click here to add this to my saved trials

Marshfield Clinic - Marshfield Center The Clinic was incorporated under Wisconsin law in 1916 and...
Click here to add this to my saved trials

Click here to add this to my saved trials

9000 W Wisconsin Ave
Milwaukee, Wisconsin 53226
Milwaukee, Wisconsin 53226
(414) 266-2000

Midwest Children's Cancer Center at Children's Hospital of Wisconsin We are the region's only independent...
Click here to add this to my saved trials

2525 Chicago Ave
Minneapolis, Minnesota 55404
Minneapolis, Minnesota 55404
(612) 813-6000

Children's Hospitals and Clinics of Minnesota - Minneapolis Children's Hospitals and Clinics of Minnesota is...
Click here to add this to my saved trials

Click here to add this to my saved trials

195 Little Albany St
New Brunswick, New Jersey 08903
New Brunswick, New Jersey 08903
(732) 235-2465

Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School As New...
Click here to add this to my saved trials

Saint Peter's University Hospital Located in New Brunswick, NJ, Saint Peter's University Hospital has been...
Click here to add this to my saved trials

160 E 34th St
New York, New York 10016
New York, New York 10016
(212) 731-5001

NYU Cancer Institute at New York University Medical Center The Perlmutter Cancer Center takes a...
Click here to add this to my saved trials

Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
Click here to add this to my saved trials

Newark Beth Israel Medical Center Newark Beth Israel Medical Center, a regional care, teaching hospital...
Click here to add this to my saved trials

Advocate Christ Medical Center Advocate Health Care, named among the nation
Click here to add this to my saved trials

Click here to add this to my saved trials

Phoenix Children's Hospital Phoenix Children's Hospital has provided hope, healing, and the best healthcare for...
Click here to add this to my saved trials

Click here to add this to my saved trials

Click here to add this to my saved trials

Mayo Clinic Cancer Center The Mayo Clinic Cancer Center is a National Cancer Institute-designated comprehensive...
Click here to add this to my saved trials

Click here to add this to my saved trials

Click here to add this to my saved trials

Click here to add this to my saved trials

Click here to add this to my saved trials

Click here to add this to my saved trials

Click here to add this to my saved trials

Click here to add this to my saved trials

3 Edmund D. Pellegrino Road
Stony Brook, New York 11794
Stony Brook, New York 11794
(631) 638-1000

Stony Brook University Cancer Center Ask a cancer survivor. Having highly advanced care close to...
Click here to add this to my saved trials

6900 Georgia Ave NW
Washington, District of Columbia 20307
Washington, District of Columbia 20307
(202) 782-6849

Walter Reed Army Medical Center The Walter Reed National Military Medical Center is one of...
Click here to add this to my saved trials

111 Michigan Ave NW
Washington, District of Columbia
Washington, District of Columbia
(202) 476-5000

Childrens National Medical Center As the nation’s children’s hospital, the mission of Children’s National Medical...
Click here to add this to my saved trials
