Brain Activities Associated With Different Facial Expressions Using Blood Oxygenation Level Dependent Functional MRI
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | November 2004 |
| End Date: | August 2008 |
Functional MRI Study of Brain Activation With Observation of Facial Expressions
Objectives: The purpose of this study is to identify areas of brain activation during the
urge to yawn. Little is known about how yawning is suppressed, or why yawning often occurs
in response to seeing another person yawn (contagious yawning). Contagious yawning is
similar to other contagious motor programs, such as the greater urge Tourette subjects feel
to tic when seeing repetitive movements or other subjects' tics, the urge to scratch when
discussing itching and scratching, or the urge to urinate when hearing running water.
Hypothetically, the urge or the suppression of this urge is modulated by a common cortical
circuit implicated in Tourette syndrome. We plan to use functional magnetic resonance
imaging (fMRI) to identify the pattern of blood oxygenation level-dependent (BOLD)
activation in the brain when normal volunteers feel the urge to yawn.
Study Population: We intend to study 25 normal, right-handed, healthy volunteers.
Study Design: Using an event-related design, we will scan subjects, using the same 3T fMRI
scanner, while showing a video of a person yawning, gaping, coughing, or doing nothing. Each
of these four action stimuli will last for four seconds, with varying interstimulus
intervals. Each video set will contain all actions displayed ten times pseudorandomly. Two
data sets will be collected from each subject and will be separated by a brief rest period.
Subjects will be instructed before the scan to watch a videotaped person perform various
behaviors, without detailing the specific actions. So as not to influence their natural
response to the yawning stimulus, we will instruct them only to keep their head still. The
variable of interest will be the activation during urge-generation, contrasted with other
control stimuli. A survey will be administered for informational purposes following the scan
to assess the subjects' general impression of their susceptibility to yawning, whether they
yawned in the scanner, whether they suppressed the urge to yawn, and if the urge to yawn
increased or decreased with the repetition of the yawning segment.
Outcome Measures: The primary outcome of this study is the activation of brain structures in
response to viewing another person yawning. In particular, we are interested in the
activation of the anterior cingulate cortex, parietal operculum, insula, supplementary motor
area, and dorsolateral prefrontal cortex as these are areas implicated in the urge to move
in response to either internal (as in Tourette syndrome) or external (as in itching from
histamine injection) states. Since the urge to yawn is the process of interest, suppression
of yawning is not relevant to the fMRI analysis.
urge to yawn. Little is known about how yawning is suppressed, or why yawning often occurs
in response to seeing another person yawn (contagious yawning). Contagious yawning is
similar to other contagious motor programs, such as the greater urge Tourette subjects feel
to tic when seeing repetitive movements or other subjects' tics, the urge to scratch when
discussing itching and scratching, or the urge to urinate when hearing running water.
Hypothetically, the urge or the suppression of this urge is modulated by a common cortical
circuit implicated in Tourette syndrome. We plan to use functional magnetic resonance
imaging (fMRI) to identify the pattern of blood oxygenation level-dependent (BOLD)
activation in the brain when normal volunteers feel the urge to yawn.
Study Population: We intend to study 25 normal, right-handed, healthy volunteers.
Study Design: Using an event-related design, we will scan subjects, using the same 3T fMRI
scanner, while showing a video of a person yawning, gaping, coughing, or doing nothing. Each
of these four action stimuli will last for four seconds, with varying interstimulus
intervals. Each video set will contain all actions displayed ten times pseudorandomly. Two
data sets will be collected from each subject and will be separated by a brief rest period.
Subjects will be instructed before the scan to watch a videotaped person perform various
behaviors, without detailing the specific actions. So as not to influence their natural
response to the yawning stimulus, we will instruct them only to keep their head still. The
variable of interest will be the activation during urge-generation, contrasted with other
control stimuli. A survey will be administered for informational purposes following the scan
to assess the subjects' general impression of their susceptibility to yawning, whether they
yawned in the scanner, whether they suppressed the urge to yawn, and if the urge to yawn
increased or decreased with the repetition of the yawning segment.
Outcome Measures: The primary outcome of this study is the activation of brain structures in
response to viewing another person yawning. In particular, we are interested in the
activation of the anterior cingulate cortex, parietal operculum, insula, supplementary motor
area, and dorsolateral prefrontal cortex as these are areas implicated in the urge to move
in response to either internal (as in Tourette syndrome) or external (as in itching from
histamine injection) states. Since the urge to yawn is the process of interest, suppression
of yawning is not relevant to the fMRI analysis.
Purpose of this study
This study will look at how perception and observation of various facial expressions may
affect the way different areas of the brain function. We hope to gain a greater
understanding of abnormal movements, such as tics, by investigating how facial expressions
affect the brain.
Background Information
This study is based on prior research that focuses on the activity and changes in different
areas of the brain depending on what people see others around them doing. An example is the
feeling of empathy one might have when looking at a sad face, or anxiety and fear when
looking at an angry face.
Who is the Study Population?
20 healthy, right-handed men and women
This study will look at how perception and observation of various facial expressions may
affect the way different areas of the brain function. We hope to gain a greater
understanding of abnormal movements, such as tics, by investigating how facial expressions
affect the brain.
Background Information
This study is based on prior research that focuses on the activity and changes in different
areas of the brain depending on what people see others around them doing. An example is the
feeling of empathy one might have when looking at a sad face, or anxiety and fear when
looking at an angry face.
Who is the Study Population?
20 healthy, right-handed men and women
- INCLUSION CRITERIA:
Subjects age 18 and older.
Subjects willing to abstain from caffeine or alcohol for 48 hours prior to the fMRI
scanning.
EXCLUSION CRITERIA:
Subjects with any abnormal findings on neurological exam.
Subjects with a positive urine pregnancy test.
Subjects who are pregnant.
Subjects with any finding on the MRI safety questionnaire which prevents them from safely
undergoing an MRI scan.
Subjects with any history of brain tumor, stroke, head trauma or a vascular malformation
as obtained by history or from imaging studies.
Subjects with any history of a severe medical condition, such as cardiovascular disease,
which would prevent them from lying flat for up to 60 minutes.
Subjects without the capacity to give informed consent.
Subjects with claustrophobia or other restrictions which prevent them from undergoing a
scan in a confined space for up to 60 minutes.
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
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