Ridaforolimus (AP23573/MK-8669) in Participants With Taxane-Resistant Androgen-Independent Prostate Cancer (AIPC)(MK-8669-017)

The primary objective of this phase II study is to assess the anti-cancer activity of weekly
ridaforolimus administration in participants with taxane-resistant AIPC. Other objectives
include evaluating experimental parameters that may predict or indicate response to mTOR
inhibition, such as effects on plasma VEGF, markers of tumoral PI3K/mTOR-pathway activity,
and proteomic analysis. The inclusion of these evaluations in this trial may provide insight
into the identification of markers that may be helpful in optimizing ridaforolimus treatment
and in identifying patients with ridaforolimus-sensitive tumors.

Inclusion Criteria:

- Male patients aged ≥ 18 years with histologically documented adenocarcinoma of the
prostate.

- Clinically refractory to hormone therapy (orchiectomy or luteinizing
hormone-releasing hormone agonist/antagonist).

- Presence of metastatic prostate cancer that fulfills at least one evaluation category
as listed: * Measurable Disease: Lesion(s) that can be accurately measured in at
least one dimension with the longest diameter ≥ 20 mm using conventional techniques
or ≥ 10 mm with spiral CT scan (or otherwise at least twice the reconstruction
interval for CT or MRI scans). *Non-measurable disease: Lesions noted on imaging
studies (including metastatic bone lesions on bone scan) or other non-measurable
lesions as defined by the modified RECIST criteria. *Progressive disease following a
cytotoxic chemotherapy regimen for prostate cancer.

- Previous treatment with at least one taxane-containing chemotherapy regimen. Patients
may have received treatment with not more than 3 additional regimens of cytotoxic
chemotherapy prior to study entry.

- Orchiectomy, or castrate levels of testosterone maintained by LHRH agonist/antagonist
< 50 ng/mL.

- Predicted life expectancy > 12 weeks.

- Eastern Cooperative Oncology Group Performance Status (ECOG PS) ≤ 2.

- Adequate renal and hepatic function, defined as: *Total serum bilirubin ≤ 1.5 x ULN
for the institution; *AST and/or ALT ≤ 3 x ULN for the institution (≤ 5 x ULN if
liver metastases are present); *Serum albumin ≥ 2.5 g/dL; *Serum creatinine ≤1.5 x
ULN for the institution (or a calculated creatinine clearance ≥ 50 mL/min/1.73m2)

- Adequate bone marrow function, defined as: *ANC ≥ 1.5 x 10^9/L; *Platelet count ≥ 100
x 10^9/L

- Serum cholesterol < 350 mg/dL and triglycerides < 400 mg/dL.

- Male patients who are not surgically sterile must agree to use reliable methods of
birth control for the duration of the study until 30 days after the last dose of
study drug.

- Able to understand and give written informed consent.

Exclusion Criteria:

- Presence of active or progressive brain metastases.

- Prior therapy with rapamycin, rapamycin analogues or tacrolimus.

- Prior non-hormonal anticancer treatment (chemotherapy, radiotherapy, immunotherapy,
biological response modifiers, signal transduction inhibitors, etc.) within 4 weeks
prior to the first dose of ridaforolimus

- Ongoing toxicity associated with prior anticancer therapy (except peripheral
neuropathy of ≤ grade 1 by NCI toxicity criteria).

- Another primary malignancy within the past three years (except for non-melanoma skin
cancer).

- Known or suspected hypersensitivity to drugs formulated with polysorbate 80 (Tween)
or any other excipient contained in the study drug.

- Known Grade 3 or 4 hypersensitivity to macrolide antibiotics (e.g., clarithromycin,
erythromycin, azithromycin).

- Significant uncontrolled cardiovascular disease.

- Active infection requiring systemic therapy.

- Known HIV infection.

- Treatment with any investigational agent within 4 weeks prior to the first dose of
ridaforolimus

- Concurrent treatment with immunosuppressive agents other than prescribed
corticosteroids at stable doses for ≥ 2 weeks prior to first planned dose of study
drug.

- Inadequate recovery from any prior surgical procedure or having undergone any major
surgical procedure within 2 weeks prior to the first dose of ridaforolimus

- Presence of any other life-threatening illness or organ system dysfunction which, in
the opinion of the Investigator, would either compromise the patient's safety or
interfere with evaluating the safety of the study drug.