Adherence With Iron Sprinkles Among High-Risk Infants

Iron deficiency is the most common known nutrient deficiency and cause of anemia in
childhood. It is associated with numerous adverse health effects, particularly delayed
mental and motor development, that may be irreversible. Despite advances of iron nutrition,
the prevalence of iron deficiency remains high among low-income infants and toddlers.
Previous studies suggest adherence with iron containing drops is low. Adherence to iron
sprinkles among children as tested in studies in less developed countries appears high.

Comparison: Children randomized to ferrous sulfate drops will be compared with children
randomized to ferrous fumarate sprinkles.

Inclusion Criteria:

- Healthy infants

- Age 5-7 months

- Presenting for 6 months well-child care

- Caregiver speaks English or Spanish

Exclusion Criteria:

- Pre-existing medical conditions with potential relation to iron deficiency or anemia
(e.g., hemoglobinopathies, gastrointestinal disorders resulting in malabsorption,
chronic renal disease, gestational age at birth of less than 36 weeks, and HIV
infection)

- Inability to speak English or Spanish

- Use of vitamin or iron supplements in the previous three months