Obesity and Weight Loss on Reproductive Function
| Status: | Terminated |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 4/21/2016 |
| Start Date: | June 2005 |
| End Date: | December 2009 |
The Effects of Morbid Obesity and Weight Loss on Reproductive Function: The Bariatric Surgery Model
The purpose of this study is to examine how obesity and weight loss following bariatric
surgery affect reproductive function. The study is particularly interested in how changes in
hormones (those produced in the stomach and fat tissue) following weight loss affect
reproductive function. Specifically, we, the researchers at Penn State University, propose
to characterize reproductive abnormalities in morbidly obese men and women. We hypothesize
that morbid obesity leads to reproductive abnormalities in men and women. We plan to examine
the short-term effects of alteration in GI hormones after bariatric surgery on reproductive
function. We hypothesize that bariatric surgery radically alters GI hormone expression,
resulting in immediate changes to the hypothalamic-pituitary-gonadal axis in men and women.
Lastly, we, the researchers, plan to examine the long-term effects of weight loss and
changes in adipokines on reproductive function. We hypothesize that the changes in adipokine
levels resulting from fat mass reduction lead to substantial long-term improvements in
reproductive function and fertility. We also hypothesize that there are sexual dimorphisms
in adipokine levels following weight loss, with women experiencing larger changes than men.
surgery affect reproductive function. The study is particularly interested in how changes in
hormones (those produced in the stomach and fat tissue) following weight loss affect
reproductive function. Specifically, we, the researchers at Penn State University, propose
to characterize reproductive abnormalities in morbidly obese men and women. We hypothesize
that morbid obesity leads to reproductive abnormalities in men and women. We plan to examine
the short-term effects of alteration in GI hormones after bariatric surgery on reproductive
function. We hypothesize that bariatric surgery radically alters GI hormone expression,
resulting in immediate changes to the hypothalamic-pituitary-gonadal axis in men and women.
Lastly, we, the researchers, plan to examine the long-term effects of weight loss and
changes in adipokines on reproductive function. We hypothesize that the changes in adipokine
levels resulting from fat mass reduction lead to substantial long-term improvements in
reproductive function and fertility. We also hypothesize that there are sexual dimorphisms
in adipokine levels following weight loss, with women experiencing larger changes than men.
Obesity may influence female reproduction through a variety of mechanisms including:
suppressing ovulation; inhibiting ovarian follicular development; and altering endometrial
development and implantation. In males, obesity may impair reproductive function by several
mechanisms including: decreasing libido, causing erectile dysfunction, influencing semen
composition, or sperm function. Therefore the long term goal of the current project is to
understand the impact of severe obesity on reproductive function and how this is influenced
by dramatic weight loss.
suppressing ovulation; inhibiting ovarian follicular development; and altering endometrial
development and implantation. In males, obesity may impair reproductive function by several
mechanisms including: decreasing libido, causing erectile dysfunction, influencing semen
composition, or sperm function. Therefore the long term goal of the current project is to
understand the impact of severe obesity on reproductive function and how this is influenced
by dramatic weight loss.
Inclusion Criteria:
- Body mass index (BMI) of greater than 40 or a BMI between 35.5-39.9 and has a weight
related health problem, such as diabetes or high blood pressure.
- Failed medical weight loss
- Ages of 18-40
- Not using hormonal contraception or sex steroids
- Subject is premenopausal and has not undergone a bilateral oophorectomy or
hysterectomy
- Subject's obesity has no medical explanation (hypothyroidism, Cushing's Syndrome,
genetic)
Exclusion Criteria:
- Not willing to make a lifelong commitment to the diet and exercise guidelines
following bariatric surgery
- Subject is pregnant or lactating
- Not willing to use barrier contraceptives or intrauterine device (IUD) to prevent
pregnancy for one year following bariatric surgery
- Post-menopausal, either surgical or natural
- Subject has had a vasectomy
- Subject is a smoker
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