Novel Strategies for Reducing Heart Disease Risk Disparities
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 45 - 75 |
| Updated: | 5/6/2018 |
| Start Date: | March 2003 |
| End Date: | December 2024 |
Heart Strategies Concentrating On Risk Evaluation (Heart SCORE) Study
This Western Pennsylvania-based study will (1) improve cardiovascular risk stratification to
identify high-risk populations, (2) identify disparities in cardiovascular risk based on
race, socioeconomic status, and geographic location, (3) evaluate mechanisms for population
differences in cardiovascular risk, and (4) implement a multidisciplinary community-based
intervention program to decrease cardiovascular risk in high-risk populations. These goals,
which are designed to eliminate ethnic and racial health disparities, are closely tied to the
National Initiative to Eliminate Racial and Ethnic Disparities in Health and the nation's
health promotion and disease prevention agenda established in Healthy People 2010.
This is a prospective cohort study of 2,000 residents of the state of Pennsylvania with
approximately equal representation of white and African American subjects. All participants
will undergo assessments of traditional and nontraditional risk factors to identify and
determine the mechanisms of population disparities in cardiovascular risk. 800 participants
who are at intermediate or high risk of cardiovascular disease will be randomly assigned to
either (1) usual care/"advice only"; or (2) a multidisciplinary behavioral modification
program to determine the most effective approach to reduce or eliminate racial, socioeconomic
and geographic disparities in cardiovascular risk. All participants will undergo long-term
follow-up for cardiovascular events.
identify high-risk populations, (2) identify disparities in cardiovascular risk based on
race, socioeconomic status, and geographic location, (3) evaluate mechanisms for population
differences in cardiovascular risk, and (4) implement a multidisciplinary community-based
intervention program to decrease cardiovascular risk in high-risk populations. These goals,
which are designed to eliminate ethnic and racial health disparities, are closely tied to the
National Initiative to Eliminate Racial and Ethnic Disparities in Health and the nation's
health promotion and disease prevention agenda established in Healthy People 2010.
This is a prospective cohort study of 2,000 residents of the state of Pennsylvania with
approximately equal representation of white and African American subjects. All participants
will undergo assessments of traditional and nontraditional risk factors to identify and
determine the mechanisms of population disparities in cardiovascular risk. 800 participants
who are at intermediate or high risk of cardiovascular disease will be randomly assigned to
either (1) usual care/"advice only"; or (2) a multidisciplinary behavioral modification
program to determine the most effective approach to reduce or eliminate racial, socioeconomic
and geographic disparities in cardiovascular risk. All participants will undergo long-term
follow-up for cardiovascular events.
Well-established disparities exist in the prevalence and outcome of cardiovascular disease
related to race and socioeconomic status (SES). Our previous work confirms these disparities
and suggests that they may be related to population differences in the prevalence of
nontraditional cardiovascular risk factors. We propose that these disparities can be
significantly reduced or eliminated by (1) a community-based intervention program that
incorporates a multidisciplinary education program led by a behavioral interventionalist, a
nutritionist and an exercise physiologist, and (2) a novel approach to cardiovascular risk
stratification that considers population differences in traditional and nontraditional risk
factors and subclinical atherosclerosis.
To successfully implement this program, particularly in traditionally underserved
communities, we have formalized a partnership between the University of Pittsburgh School of
Medicine and Graduate School of Public Health, the Pittsburgh Mind-Body Center, and the
Pittsburgh Theological Seminary, Urban League of Pittsburgh, and Jewish Healthcare
Foundation. This partnership is positioned to study the following specific aims:
1. To determine whether a community-based intervention program that incorporates a
multidisciplinary education program led by a behavioral interventionalist, a
nutritionist, and an exercise physiologist can reduce racial and socioeconomic
disparities in cardiovascular risk in intermediate and high risk populations.
2. To ascertain whether a comprehensive assessment of nontraditional risk factors and
subclinical atherosclerosis can provide incremental value above and beyond traditional
risk assessment in identifying individuals at high cardiovascular risk.
related to race and socioeconomic status (SES). Our previous work confirms these disparities
and suggests that they may be related to population differences in the prevalence of
nontraditional cardiovascular risk factors. We propose that these disparities can be
significantly reduced or eliminated by (1) a community-based intervention program that
incorporates a multidisciplinary education program led by a behavioral interventionalist, a
nutritionist and an exercise physiologist, and (2) a novel approach to cardiovascular risk
stratification that considers population differences in traditional and nontraditional risk
factors and subclinical atherosclerosis.
To successfully implement this program, particularly in traditionally underserved
communities, we have formalized a partnership between the University of Pittsburgh School of
Medicine and Graduate School of Public Health, the Pittsburgh Mind-Body Center, and the
Pittsburgh Theological Seminary, Urban League of Pittsburgh, and Jewish Healthcare
Foundation. This partnership is positioned to study the following specific aims:
1. To determine whether a community-based intervention program that incorporates a
multidisciplinary education program led by a behavioral interventionalist, a
nutritionist, and an exercise physiologist can reduce racial and socioeconomic
disparities in cardiovascular risk in intermediate and high risk populations.
2. To ascertain whether a comprehensive assessment of nontraditional risk factors and
subclinical atherosclerosis can provide incremental value above and beyond traditional
risk assessment in identifying individuals at high cardiovascular risk.
Inclusion Criteria:
- Men and women age 45-75 years
Exclusion Criteria:
- Comorbidity that is expected to limit life expectancy to <5 years
- Inability to undergo baseline or annual follow-up visits
- Pregnancy (exclude women from Xray studies)
We found this trial at
1
site
University of Pittsburgh The University of Pittsburgh is a state-related research university, founded as the...
Click here to add this to my saved trials
