Depression, Epinephrine, and Platelet Function
| Status: | Completed |
|---|---|
| Conditions: | Depression, Depression, Major Depression Disorder (MDD) |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 4/21/2016 |
| Start Date: | February 2002 |
| End Date: | January 2009 |
Do Antidepressants Reverse the Effects of Early Life Stress on the Brain and Thrombovascular System and Improve Psychological, Neuroendocrine, and Platelet Function: A Study of Men and Women With Childhood Abuse.
Men and women who have suffered sexual and/or physical abuse before the age of 12 are at
increased risk for anxiety and mood disorders, other serious psychiatric disorders, and
likely medical illnesses. What is not known is whether adult survivors of childhood
adversity experience heightened negative emotions and increased physical responses due to
altered norepinephrine or serotonin systems in their brains and bodies. The investigators
expect to see that survivors of childhood adversity experience heightened negative emotions
and increased physical responses to stress.
increased risk for anxiety and mood disorders, other serious psychiatric disorders, and
likely medical illnesses. What is not known is whether adult survivors of childhood
adversity experience heightened negative emotions and increased physical responses due to
altered norepinephrine or serotonin systems in their brains and bodies. The investigators
expect to see that survivors of childhood adversity experience heightened negative emotions
and increased physical responses to stress.
Inclusion Criteria:
Exclusion Criteria:
- Individuals who are suicidal, psychotic, or with bipolar depression
- alcohol or substance abuse or
- regularly use medications which alter mood or blood vessel function (zolpidem or
zalpelon, aspirin, nonsteroidal antiinflammatory drugs, sympatholytics, theophylline,
central acting agonists, beta-blockers, coumadin, nitrates, triazolobenzodiazapines,
or use steroids (testosterone-patch or pill form), use tryptophan or monoamine
oxidase inhibitors (MAOIs),
- have narrow-angle glaucoma, liver disease,
- severe allergies (especially to antidepressants similar to escitalopram or
desipramine)
- seizures, or a serious medical disorder (e.g. hypothyroidism) that is unstable or is
untreated.
- Depressed patients with a prior history of severe adverse events associated with
SSRIs or TCAs will not be accepted into the study.
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