Phase II Trial of Pentostatin in Steroid Refractory Acute Graft Versus Host Disease

Inclusion Criteria:

- Must have biopsy proven grade II-IV acute GVHD refractory to systemic corticosteroids

- No chronic GVHD

- Age ≥ 18 years

- Evidence of myeloid engraftment (ANC ≥ 0.5 x 109/l)

- Performance status 0-3

Exclusion Criteria:

- Patients on mechanical ventilation or who have resting O2 saturation <90% by
pulse-oximetry.

- Patients on renal dialysis or who have an estimated creatinine clearance of < 30
ml/min/1.73 m2.

- Patients with documented clinical infection (progressive symptoms despite antibiotics
or continued fever) cannot be enrolled on study until infection is controlled.