Vitamin D Administration in the Nursing Home
| Status: | Completed |
|---|---|
| Conditions: | Osteoporosis, Other Indications, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology, Rheumatology, Other |
| Healthy: | No |
| Age Range: | 55 - Any |
| Updated: | 4/21/2016 |
| Start Date: | June 2001 |
| End Date: | November 2004 |
Intermittent Vitamin D Administration in the Nursing Home: Impact on Vitamin D Status, Falls, Bone Turnover and Bone Density
Administration of vitamin D 50,000 units once monthly will:
- Maintain serum 25-OH vitamin D above 20 ng/ml
- Reduce falls
- Increase calcaneal BMD
- Reduce bone turnover
- Be well tolerated: volunteers will not develop hypercalcemia
- Improve performance on a swallowing quality of life questionnaire
- Maintain serum 25-OH vitamin D above 20 ng/ml
- Reduce falls
- Increase calcaneal BMD
- Reduce bone turnover
- Be well tolerated: volunteers will not develop hypercalcemia
- Improve performance on a swallowing quality of life questionnaire
1. Research questions: We propose a prospective double-blind, randomized, placebo-controlled
trial of once-monthly vitamin D oral capsules (50,000 units) in nursing-home residents.
Subjects from several Wisconsin nursing homes were randomized to receive once-monthly
vitamin D oral capsules (50,000 units) or placebo. Blood levels of 25-OH D, parathyroid
hormone, serum calcium, and a marker of bone turnover will be measured periodically by
standard lab assays. Swallowing quality of life was measured by questionnaire. Appropriate
statistical tests (paired T tests, 95% confidence intervals will be calculated with the
large sample approximation for binomial variables, other).
trial of once-monthly vitamin D oral capsules (50,000 units) in nursing-home residents.
Subjects from several Wisconsin nursing homes were randomized to receive once-monthly
vitamin D oral capsules (50,000 units) or placebo. Blood levels of 25-OH D, parathyroid
hormone, serum calcium, and a marker of bone turnover will be measured periodically by
standard lab assays. Swallowing quality of life was measured by questionnaire. Appropriate
statistical tests (paired T tests, 95% confidence intervals will be calculated with the
large sample approximation for binomial variables, other).
Inclusion Criteria:
- Male or Female
- Nursing Home Resident in Wisconsin
Exclusion Criteria:
- Renal Failure
- Hypercalcemia
- Metastatic Cancer
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