Rapid Emergency Department Heart Failure Outpatient Trial (REDHOT II)

This is a patient-randomized clinical study consisting of patients who present to the ED
requiring treatment and/or admission for HF. At each site, patients will be randomized into
either a control arm or an experimental arm. Serial blood samples will be collected from all
patients throughout their stay in the ED and the hospital. In the experimental arm, the
Triage® BNP test will be performed on all blood samples collected and each BNP result will
be made available to the attending physicians immediately. In the control arm, blood samples
will not be analyzed on-site for BNP but instead sent directly to Biosite Inc. for testing.A
comparison will be made between the control and experimental arms of the study to determine
if there are any significant differences in length of stay, re-hospitalizations, all cause
mortality, BNP levels, quality of life, and costs to treat patients.

Inclusion Criteria:

Age 18 and older Patient needs treatment for HF

Exclusion Criteria:

Current MI or ACS with ST deviation of 1 mm or greater Renal failure requiring dialysis
Undergone hemodialysis within the last month Enrollment (Baseline) Triage® BNP
concentration = 100 pg/ml or less Enrolled in any other drug trial or receiving an
experimental treatment for HF.