The Role of the Omentum in the Treatment of Morbid Obesity
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 4/21/2016 |
| Start Date: | January 2005 |
| End Date: | December 2016 |
The purpose of this research is to determine some of the reasons that blood sugar and
insulin levels improve after bariatric surgery but before weight loss begins, as well as why
people respond differently to weight loss surgery. It will also examine whether removing the
fat around the stomach and large intestine (the omentum) will improve weight loss. Finally,
it will see why there are differences between Whites and African Americans who have weight
loss surgery.
insulin levels improve after bariatric surgery but before weight loss begins, as well as why
people respond differently to weight loss surgery. It will also examine whether removing the
fat around the stomach and large intestine (the omentum) will improve weight loss. Finally,
it will see why there are differences between Whites and African Americans who have weight
loss surgery.
The purpose of this research is to tease out the mechanisms related to changes in insulin
sensitivity, metabolism, hormones, and body composition following bariatric surgery. Because
preliminary data indicate differing responses to this surgery, both Caucasian and African
American adults, scheduled for RYGB, are being recruited to participate. It is believed that
the omentum contributes to hepatic insulin resistance, both because of the increased
delivery of NEFAs via the portal vein, and the increased production of cytokines. Because of
this, it is postulated that removing the omentum as part of bariatric surgery will speed up
the reversal of insulin resistance and diminish racial differences in response to the
surgery.
Data are derived from tissue and blood samples obtained operatively (from individuals having
bariatric surgery and other abdominal operations), as well as during
hyperinsulinemic-euglycemic clamps, from indirect calorimetry, DEXA, Health-related Quality
of Life surveys, and 24-hour urine samples. There were 66 participants randomized to
omentectomy/no omentectomy. A post hoc data power analysis determined that this number of
subjects is sufficient for data analysis.
sensitivity, metabolism, hormones, and body composition following bariatric surgery. Because
preliminary data indicate differing responses to this surgery, both Caucasian and African
American adults, scheduled for RYGB, are being recruited to participate. It is believed that
the omentum contributes to hepatic insulin resistance, both because of the increased
delivery of NEFAs via the portal vein, and the increased production of cytokines. Because of
this, it is postulated that removing the omentum as part of bariatric surgery will speed up
the reversal of insulin resistance and diminish racial differences in response to the
surgery.
Data are derived from tissue and blood samples obtained operatively (from individuals having
bariatric surgery and other abdominal operations), as well as during
hyperinsulinemic-euglycemic clamps, from indirect calorimetry, DEXA, Health-related Quality
of Life surveys, and 24-hour urine samples. There were 66 participants randomized to
omentectomy/no omentectomy. A post hoc data power analysis determined that this number of
subjects is sufficient for data analysis.
Inclusion Criteria:
- BMI > 40
- BMI > 35 with co-morbidities
- normal creatinine/liver labs
- insurance approval for RYGB or resources to self-pay
- proximity to Nashville, TN
Exclusion Criteria:
- use of anticoagulants, steroids, therapeutic niacin
- previous bariatric surgery
We found this trial at
1
site
1211 Medical Center Dr
Nashville, Tennessee 37232
Nashville, Tennessee 37232
(615) 322-5000
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
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