Behavioral Therapy Combined With Carbidopa/Levodopa for the Treatment of Cocaine Dependence
| Status: | Completed |
|---|---|
| Conditions: | Psychiatric, Psychiatric, Pulmonary |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 4/21/2016 |
| Start Date: | March 2000 |
| End Date: | October 2007 |
Behavioral Strategies to Maximize the Efficacy of Pharmacotherapy for Cocaine Dependence: Relapse Prevention With Contingency Management Procedures
Cocaine dependence is a major public health problem; an effective primary treatment for
cocaine dependent individuals has yet to be found. The purpose of this study is to examine
the effectiveness of levodopa and carbidopa in treating cocaine dependent individuals. In
addition, this study will examine the effects of incentive rewards for treatment compliance.
cocaine dependent individuals has yet to be found. The purpose of this study is to examine
the effectiveness of levodopa and carbidopa in treating cocaine dependent individuals. In
addition, this study will examine the effects of incentive rewards for treatment compliance.
Cocaine is a strong central nervous system stimulant that is widely abused throughout the
United States. Due to its widespread use, it is important to develop an effective treatment
for cocaine dependence. Levodopa is a medication that is used alone or in combination with
carbidopa to treat Parkinson's disease. The purpose of this study is to determine the
possible interactions between behavioral interventions and carbidopa/levodopa in order to
treat cocaine dependent individuals.
This study will last 12 weeks and will involve two phases. The first phase will include
three therapy conditions: 1) clinical management only, 2) clinical management and relapse
prevention therapy, and 3) clinical management, relapse prevention therapy, and contingency
management. All of the conditions in the first phase will be evaluated incrementally under
active and placebo conditions while participants receive carbidopa/levodopa.
The second phase of the study will examine the contingency management procedure
applications. Each of the three contingency management procedure applications targets
specific behaviors that, when reinforced, may interact with carbidopa/levodopa to produce
clinical benefits. Participants will receive relapse prevention therapy combined with a
contingency management procedure that targets clinic attendance, medication compliance, and
cocaine abstinence. Study visits will occur weekly throughout the study. In addition,
participants will complete a one-year follow-up visit.
United States. Due to its widespread use, it is important to develop an effective treatment
for cocaine dependence. Levodopa is a medication that is used alone or in combination with
carbidopa to treat Parkinson's disease. The purpose of this study is to determine the
possible interactions between behavioral interventions and carbidopa/levodopa in order to
treat cocaine dependent individuals.
This study will last 12 weeks and will involve two phases. The first phase will include
three therapy conditions: 1) clinical management only, 2) clinical management and relapse
prevention therapy, and 3) clinical management, relapse prevention therapy, and contingency
management. All of the conditions in the first phase will be evaluated incrementally under
active and placebo conditions while participants receive carbidopa/levodopa.
The second phase of the study will examine the contingency management procedure
applications. Each of the three contingency management procedure applications targets
specific behaviors that, when reinforced, may interact with carbidopa/levodopa to produce
clinical benefits. Participants will receive relapse prevention therapy combined with a
contingency management procedure that targets clinic attendance, medication compliance, and
cocaine abstinence. Study visits will occur weekly throughout the study. In addition,
participants will complete a one-year follow-up visit.
Inclusion Criteria:
- Meets DSM-IV criteria for current cocaine dependence
- Provides at least one positive urine test for cocaine during study screening
- Good general health, based on a physical exam, lab tests, and an electrocardiogram
- Reads and writes English at a sixth grade level
Exclusion Criteria:
- Current Axis I depressive, psychotic, or anxiety disorder
- Currently in jail
- Pregnant or breastfeeding
- Requires certain medications
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