Escitalopram in the Treatment of Dysthymic Disorder, Double Blind

This is a 12-week double-blind placebo-controlled study of Escitalopram in treatment of
Dysthymic Disorder (low-grade chronic depression), with a 12 week open-label extension
phase.

Flexible dosing to a maximum of 40 mg per day will be used. It is hypothesized that
Escitalopram will be superior to placebo in improving depression, as well as psychosocial,
temperamental, and cognitive functioning. Blood cytokine levels will also be measured at
weeks 0, 12, and 24 to determine their relationship to depressive symptoms and improvement.

Inclusion Criteria:

- Male and female outpatients 18-65 years of age.

- Patients with a Diagnostic and Statistical Manual, fourth edition (DSM-IV) diagnosis
of dysthymic disorder.

- Subject must be considered reliable.

- Patients will have a total of 12 or higher on the Hamilton Depression Scale (24
items) at baseline.

Exclusion Criteria:

- Patients with a DSM-IV diagnosis of Delirium, Dementia, and Amnestic, and other
Cognitive Disorders.

- Patients who plan to produce a pregnancy within the next 6 months, or patients who
are pregnant or nursing women.

- Patients who have a history of non-response to two or more sufficient trials of
antidepressant medication (as defined in Table 1).

- Patients with a principal diagnosis meeting DSM-IV criteria for:

- Major Depressive Disorder, current

- Bipolar Disorder or cyclothymia .Schizophrenia, Delusional (Paranoid) Disorders
and Psychotic Disorders not elsewhere classified.

- Anorexia Nervosa or Bulimia

- Patients who, within the past 6 months, met DSM-IV criteria for abuse of or
dependence on any drug, including alcohol, excluding caffeine and tobacco.

- Patients who have taken psychotropic medication or herbal preparations with putative
psychotropic effects within 7 days prior to Visit 2. Patients taking a monoamine
oxidase inhibitor (a type of antidepressant) (MAOI) must have a washout period of 14
days prior to visit 2, and patients taking fluoxetine must have a washout period of
at least 4 weeks prior to Visit 2.

- Patients who would pose a serious risk for suicide during the course of the study, as
evidenced by one of the following:

- Report of having a specific plan for killing themselves

- A score of 3 or higher on the Hamilton Depression Rating Scale item #3 as rated
by the treating clinician at Week 0, (indicative of active suicidal thoughts or
behaviors)

- A suicide attempt within the past 12 months requiring emergency room visit,
medical or psychiatric hospitalization, or otherwise deemed to be
life-threatening (e.g. an overdose of > 1 week's dose of medication.

- Patients with unstable medical conditions, such as acute hyperthyroidism, uncorrected
hypothyroidism, undiagnosed fever, uncontrolled angina, or any other serious medical
illness, including any cardiovascular, hepatic, respiratory, hematological,
endocrinologic o neurologic disease, or any clinically significant laboratory
abnormality.

- Patients who lack the capacity to proved informed consent

- 50% or greater decrease in HDRS total score from visit 2 to visit 3 or a
CGI-Improvement score of 1 ("very much improved") or 2 ("much improved") at Visit 3

- Patients receiving CGI Improvement scores of 6 ("much worse") or 7 ("very much
worse") for two consecutive visits will be withdrawn from the study.

- Patients who meet criteria for Major Depressive Disorder at any time during the
course of the study will be withdrawn from the study.