Organ Preservation Media Investigation

Kidney transplantation remains limited by four problems: 1) a too high rate of delayed graft
function, 2) early loss of kidneys from chronic rejection, 3) donor kidney shortages, and 4)
the need for immunomodulating treatments. Improved cold storage methods can significantly
impact on the first 3 of these 4 major problems. The device to be tested is a modification
of the existing Viaspan organ preservation solution. The modification of this solution
combines four compounds: Bovine neutrophil peptide-1 (BNP-1), Substance P (SP), Insulin-like
growth factor-1 (IGF-1), and Nerve Growth Factor (NGF). This solution will be added to
Viaspan for preservation of donor kidneys. Preclinical data indicates that trophic factor
deprivation during cold storage is a significant and previously unrecognized mechanism of
injury in cold stored kidneys. The aim of this study is improved graft function, decreasing
early graft loss due to rejection, and decreasing the donor organ shortage.