Coronary Heart Disease Incidence: Depression & Inflammation Risk
| Status: | Completed |
|---|---|
| Conditions: | Depression, Depression, Peripheral Vascular Disease, Peripheral Vascular Disease, Cardiology, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | August 2005 |
| End Date: | May 2010 |
To examine the associations among depression, inflammation, and coronary heart disease using
an existing data base and associated plasma samples.
an existing data base and associated plasma samples.
BACKGROUND:
Classic risk factors for coronary heart disease (CHD) do not yet predict the majority of new
cases. Of the novel risk factors recently explored, elevated depressive symptoms have been
found in a number of prospective studies to predict new CHD cases, as have inflammatory
markers, including high sensitivity C-Reactive Protein (CRP), interleukin-6 (IL-6), and
intercellular adhesion molecule. Interestingly, depression and inflammatory markers have
high covariation, and intervention studies indicate that reducing depression may reduce
peripheral inflammation, while successfully treating inflammation may ameliorate depressive
symptoms. It becomes critical then to know if these candidate CHD risk factors are
independent or dependent of the other in the prediction of CHD incidence.
DESIGN NARRATIVE:
The study will determine if depressive symptoms and inflammatory markers are independent or
dependent CHD risk factors, when controlling for the other known CAD risk factors. A
population-based prospective study (the Nova Scotia Health Survey; NSHS95) was conducted
almost 10 years ago, in which participants were randomly selected from the socialized
medical registry, which includes all citizens. All classic CHD risk factors were obtained at
baseline (age, sex, race, fasting lipids, diabetic status, family CHD history, resting blood
pressure, exercise levels, body mass index, smoking status, and socioeconomic status).
Depressive symptoms as assessed by the Center for Epidemiological Studies Depression scale
were also obtained at baseline. Plasma blood samples were obtained and maintained in a -80
degree (Celsius) freezer. Participants gave permission for medical registry records to be
linked to their survey data, so that objectively documented previous and future CAD events
could be detected. The study will assay plasma samples for CRP, IL-6 and ICAM-1 and then
statistically model the associations among depression, inflammation and CHD incidence.
Classic risk factors for coronary heart disease (CHD) do not yet predict the majority of new
cases. Of the novel risk factors recently explored, elevated depressive symptoms have been
found in a number of prospective studies to predict new CHD cases, as have inflammatory
markers, including high sensitivity C-Reactive Protein (CRP), interleukin-6 (IL-6), and
intercellular adhesion molecule. Interestingly, depression and inflammatory markers have
high covariation, and intervention studies indicate that reducing depression may reduce
peripheral inflammation, while successfully treating inflammation may ameliorate depressive
symptoms. It becomes critical then to know if these candidate CHD risk factors are
independent or dependent of the other in the prediction of CHD incidence.
DESIGN NARRATIVE:
The study will determine if depressive symptoms and inflammatory markers are independent or
dependent CHD risk factors, when controlling for the other known CAD risk factors. A
population-based prospective study (the Nova Scotia Health Survey; NSHS95) was conducted
almost 10 years ago, in which participants were randomly selected from the socialized
medical registry, which includes all citizens. All classic CHD risk factors were obtained at
baseline (age, sex, race, fasting lipids, diabetic status, family CHD history, resting blood
pressure, exercise levels, body mass index, smoking status, and socioeconomic status).
Depressive symptoms as assessed by the Center for Epidemiological Studies Depression scale
were also obtained at baseline. Plasma blood samples were obtained and maintained in a -80
degree (Celsius) freezer. Participants gave permission for medical registry records to be
linked to their survey data, so that objectively documented previous and future CAD events
could be detected. The study will assay plasma samples for CRP, IL-6 and ICAM-1 and then
statistically model the associations among depression, inflammation and CHD incidence.
Inclusion Criteria:
- Age 18 and over
- Able to speak English
- Enrolled in the Nova Scotia Health Study (NSHS95)
Exclusion Criteria:
- Pregnant
- Active military personnel
- Lived in Nova Scotia province for less than 3 months
- Unable to provide informed consent
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