Vorinostat in Treating Patients With Low-Grade Non-Hodgkin's Lymphoma

PRIMARY OBJECTIVES:

I. To evaluate the anti-tumor activity of SAHA (vorinostat) as assessed by the objective
response rate, time to progression and survival in subjects with advanced lymphoma.

II. To assess the toxicity profile of SAHA in this patient population. III. To perform
correlative laboratory investigations to confirm modulation of chromatin acetylation as the
biologic target and attempt to gain insight into the downstream molecular mechanisms involved
in the induction of apoptosis mediated by SAHA.

OUTLINE:

Patients receive vorinostat orally (PO) twice daily (BID) on days 1-14. Treatment repeats
every 21 days for up to 12 courses in the absence of disease progression or unacceptable
toxicity.

After completion of study treatment, patients are followed up every 3 months for 1 year and
then every 6 months for 2 years.

Inclusion Criteria:

- Patients must have histologically or cytologically confirmed relapsed/refractory
indolent Non-Hodgkin's lymphoma (Included in this category are relapsed/refractory
follicular center lymphomas grade I, II, III, relapsed /refractory marginal zone
B-cell lymphoma (nodal and extranodal), relapsed/refractory mantle cell lymphoma)

- Patients must have measurable disease by computed tomography (CT) scan. positron
emission tomography (PET) scan evaluations are desirable but not mandatory, so that
patients with negative PET scans but measurable disease by CT are eligible

- Patients may have had up to four prior chemotherapeutic regimens; steroids alone and
local radiation do not count as regimens (radiotherapy must have been completed at
least 14 days prior to starting SAHA); rituxan alone does not count as a regimen,
however, Bexxar or Zevalin do; the most recent therapy must have failed to induce a
complete response, or there must be disease progression or recurrence after the most
recent therapy

- Patients may be enrolled who relapse after autologous stem cell transplant if they are
at least three months after transplant, and after allogeneic transplant if they are at
least six months post transplant; to be eligible after either type of transplant,
patients must have achieved platelet counts greater than 100,000/mcL, and white blood
cell (WBC) greater than 1,000/mcL at some point after their transplant, and should
have no active related infections (i.e. fungal or viral); in the case of allogeneic
transplant relapse, there should be no active acute graft versus host disease (GvHD)
of any grade, and no chronic graft versus host disease other than mild skin, oral, or
ocular GvHD not requiring systemic immunosuppression

- Life expectancy of greater than 3 months

- Eastern Cooperative Oncology Group (ECOG) performance status #2 (Karnofsky >= 60%)

- Absolute neutrophil count >= 1,000/mcL

- Platelets >= 100,000/mcL

- Total bilirubin within normal institutional limits; patients with elevation of
unconjugated bilirubin alone, as in Gilbert's Disease, are eligible

- Aspartate aminotransferase (AST)(serum glutamic oxaloacetic transaminase
[SGOT])/alanine aminotransferase (ALT)(serum glutamate pyruvate [SGPT]) =< 2.5 x
institutional upper limit of normal

- Creatinine up to and including 2 mg/dl

- Premenopausal women must have a negative serum pregnancy test prior to entry on this
study; the effects of SAHA on the developing human fetus at the recommended
therapeutic dose are unknown; women of child-bearing potential and men must agree to
use adequate contraception (hormonal or barrier method of birth control; abstinence)
prior to study entry and for the duration of study participation; should a woman
become pregnant or suspect she is pregnant while participating in this study, she
should inform her treating physician immediately

- Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

- Patients who have had chemotherapy within 4 weeks, rituximab within three months
(unless there is evidence of progression) or radiotherapy within 2 weeks or those who
have not recovered from adverse events due to agents administered more than 4 weeks
earlier are excluded; this does not include use of steroids, which may continue until
two days prior to enrollment; low dose chlorambucil should be stopped two weeks prior
to beginning SAHA; valproic acid should be stopped at least two weeks prior to
enrollment; nitrosoureas and mitomycin should be stopped 6 weeks prior to enrollment

- Patients may not be receiving any other investigational agents

- Patients with known brain metastases are excluded from this clinical trial unless the
metastases are controlled after therapy and have not been treated with steroids within
the past two months

- History of allergic reactions attributed to compounds of similar chemical or biologic
composition to SAHA

- There must be no plans for the patient to receive concurrent hormonal, biological or
radiation therapy

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements

- Pregnant women are excluded from this study; breastfeeding should be discontinued if
the mother is treated with SAHA

- Human immunodeficiency virus (HIV)-positive patients receiving combination
antiretroviral therapy are ineligible

- Patients with other active malignancies are ineligible for this study