The Effect of Caffeine on Postextubation Adverse Respiratory Events in Children With Obstructive Sleep Apnea (OSA).
| Status: | Completed |
|---|---|
| Conditions: | Insomnia Sleep Studies, Hospital, Pulmonary, Pulmonary |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases, Other |
| Healthy: | No |
| Age Range: | Any - 18 |
| Updated: | 4/21/2016 |
| Start Date: | September 2003 |
| End Date: | May 2008 |
A Pilot Study to Evaluate if Caffeine Helps Children With Obstructive Sleep Apnea Recover Faster From Anesthesia, and With Less Complications After General Anesthesia for Tonsillectomy and Adenoidectomy.
This is a research study using caffeine in children who have an obstructive sleep apnea
(OSA). OSA means children who stop breathing during their sleep due to obstruction in their
airway. The purpose of this study is to determine whether caffeine when given in the vein,
will wake children up faster and decrease post-anesthesia airway obstruction, as well as the
safety and if the drug agrees with the child compared to a placebo (an inactive or dummy
agent).
(OSA). OSA means children who stop breathing during their sleep due to obstruction in their
airway. The purpose of this study is to determine whether caffeine when given in the vein,
will wake children up faster and decrease post-anesthesia airway obstruction, as well as the
safety and if the drug agrees with the child compared to a placebo (an inactive or dummy
agent).
Patients with OSA are reported to have a higher rate of severe respiratory complications
associated with upper airway obstruction during anesthesia and sedation or immediately after
anesthesia. Children with OSA (especially those under three years of age, those with severe
OSA, cerebral palsy or craniofacial anomalies) are at increased risks for post-operative
complications, and require careful monitoring post-operatively.
Although the etiology of obstructive sleep apnea is mainly obstruction due to anatomical and
neuromuscular abnormalities, we believe that a central element may contribute to OSA.
The aim of this study is to evaluate whether administration of caffeine to children with
OSA, scheduled for elective T & A under general anesthesia contributes to a faster recovery,
less post-operative complications, and a shorter stay in the PACU, DSU and the hospital.
associated with upper airway obstruction during anesthesia and sedation or immediately after
anesthesia. Children with OSA (especially those under three years of age, those with severe
OSA, cerebral palsy or craniofacial anomalies) are at increased risks for post-operative
complications, and require careful monitoring post-operatively.
Although the etiology of obstructive sleep apnea is mainly obstruction due to anatomical and
neuromuscular abnormalities, we believe that a central element may contribute to OSA.
The aim of this study is to evaluate whether administration of caffeine to children with
OSA, scheduled for elective T & A under general anesthesia contributes to a faster recovery,
less post-operative complications, and a shorter stay in the PACU, DSU and the hospital.
Inclusion Criteria:
- Children between 2.5-18 years old
- Diagnosed with obstructive sleep apnea
- Undergoing elective tonsillectomy and adenoidectomy
Exclusion Criteria:
- Age below 2.5 or above 18 years
We found this trial at
1
site
Houston, Texas
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