Study Evaluating HKI-272 (Neratinib) In Subjects With Advanced Breast Cancer



Status:Completed
Conditions:Breast Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:8/16/2018
Start Date:August 4, 2006
End Date:January 30, 2018

Use our guide to learn which trials are right for you!

Phase 2 Study of HKI-272 In Subjects With Advanced Breast Cancer

The purpose of this study is to learn whether neratinib is safe and effective in treating
women with advanced human epidermal growth factor receptor 2 (HER2) positive breast cancer.

Arm A: HER2 gene amplification and disease progression following at least 6 weeks of standard
doses of Herceptin; Arm B: HER2 gene amplification and no prior Herceptin or HER2-targeted
treatment.

Inclusion Criteria:

- Pathologic diagnosis of breast cancer and current stage IIIB, IIIC, or IV

- Progression following at least 6 weeks of standard doses of Herceptin (Arm A only)

- Over-expression of HER2

- Tumor tissue available and adequate for analysis at screening

- At least one measurable lesion

Exclusion Criteria:

- Prior treatment with Herceptin (Arm B only)

- More than 4 prior cytotoxic chemotherapy regimens

- Subjects with bone or skin as the only site of measurable disease

- Inadequate cardiac function

- Major surgery, chemotherapy, radiotherapy, investigational agents or other cancer
therapy within 1 week of treatment day 1

- Active central nervous system metastases

- Pregnant or breastfeeding women

- Inability to swallow the HKI-272 capsules
We found this trial at
14
sites
2730 University Boulevard West
Bethesda, Maryland 20817
?
mi
from
Bethesda, MD
Click here to add this to my saved trials
330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
?
mi
from
Boston, MA
Click here to add this to my saved trials
2010 E 90th St
Cleveland, Ohio 44195
(866) 223-8100
Cleveland Clinic Taussig Cancer Center At Taussig Cancer Institute, more than 250 highly skilled doctors,...
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
One Medical Center Drive
Lebanon, New Hampshire 03756
(603) 653-9000
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center Norris Cotton Cancer Center at DHMC in...
?
mi
from
Lebanon, NH
Click here to add this to my saved trials
12605 East 16th Avenue
Aurora, Colorado 80045
720-848-0000
University of Colorado Hospital, Site Top medical professionals, superior medicine and progressive change make University...
?
mi
from
Aurora, CO
Click here to add this to my saved trials
Baltimore, Maryland 21204
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
?
mi
from
Boston, MA
Click here to add this to my saved trials
1 Boston Medical Center Place
Boston, Massachusetts 02118
617.638.8000
Boston University Medical Center Boston Medical Center is an extraordinary community of health care providers...
?
mi
from
Boston, MA
Click here to add this to my saved trials
Boston, Massachusetts 02133
?
mi
from
Boston, MA
Click here to add this to my saved trials
121 Boulevard de Waterloo
Brussels, 1000
?
mi
from
Brussels,
Click here to add this to my saved trials
New Brunswick, New Jersey 08901
?
mi
from
New Brunswick, NJ
Click here to add this to my saved trials
Seattle, Washington 98101
(888) 862-2737
Virginia Mason Medical Center Established in 1920, Virginia Mason began as an 80-bed hospital with...
?
mi
from
Seattle, WA
Click here to add this to my saved trials
Shreveport, Louisiana 71103
?
mi
from
Shreveport, LA
Click here to add this to my saved trials
Zion, Illinois 60099
?
mi
from
Zion, IL
Click here to add this to my saved trials