Safety, Efficacy and Acceptability of Flavocoxid (Limbrel)A Pilot Study

Safety, Efficacy and acceptability of Flavocoxid (Limbrel) compared with Naproxen in
Subjects with Osteoarthritis of the Knee. A Pilot Study

Inclusion Criteria:

OA of the knee,K-L grade 2-3 in general good health is currently taking an NSAID or COX-2
inhibitor -

Exclusion Criteria:

pregant or nursing women grade 1 or 4 OA any significant medical condition that in the
opinion of the physician might put the subject at risk in this study any form of
arthropathy other than OA any condition that might confound the evaluation of the pain,
stiffness or function of the target joint intra-articular cotticosteroid inkection in the
target joint within 3 month of the screening visit concomitant use of other
anti-inflammatory or anti arthritic medication or products(including OTC and herbal
preparations) Low dose aspirin for cardio-protection is allowed concomitant use of
coumadin or other anticoagulant or anti-platelet medication concomitant use of
gastro-protectiv medications including, but not limited to, H2 blockers and proton pump
inhibitors, including OTC and herbal products History of allergy to Flavonoids