Protocol for Postmenopausal Women at Increased Risk of Developing Breast Cancer
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Breast Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/15/2017 |
| Start Date: | May 2005 |
| End Date: | November 2017 |
Correlation of SNP Patterns With Fine Needle Aspiration Cytomorphology in High Risk Postmenopausal Women
A study to examine the potential associations between common single nucleotide polymorphisms
and pre-cancerous conditions in breast tissue specimens from postmenopausal women.
and pre-cancerous conditions in breast tissue specimens from postmenopausal women.
A study to examine the correlation between single nucleotide polymorphisms (SNPs) affecting
steroid and carcinogen metabolism and benign breast tissue cytomorphology collected via
random periareolar fine needle aspiration in postmenopausal women at increased risk for
breast cancer and taking hormone replacement therapy.
steroid and carcinogen metabolism and benign breast tissue cytomorphology collected via
random periareolar fine needle aspiration in postmenopausal women at increased risk for
breast cancer and taking hormone replacement therapy.
Inclusion Criteria:
- postmenopausal women on or off hormone replacement therapy
- at high risk of developing breast cancer determined by family or personal history
- postmenopausal women not on hormone replacement therapy for at minimum six months
prior to corresponding aspiration
- willing to participate in companion protocol (KUMC HSC#4601) for random periareolar
fine needle aspiration (RPFNA) for correlational studies
Exclusion Criteria:
- women who have been on raloxifene, tamoxifen, letrozole, anastrozole or exemestane
within the six months prior to RPFNA.
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