Computer-Based Training for Cognitive Enhancement: Classroom Study

The purpose of this study is to test the new progressions design of a computer-based
training program and to demonstrate the effectiveness of this refined cognitive training
regimen on participants' performance on normed neuropsychological measures.

Subjects meeting eligibility criteria and providing written, informed consent will complete
40 one hour sessions of a computer based training program.

Inclusion Criteria:

A)Participants must be at least 60 years old B)Participants must have a Mini-Mental State
Exam (MMSE) score of 24 or higher to ensure that participants do not meet common criteria
for dementia C)Participants must be a native English speaker D)Participants must be able
to see well enough to read the consent form E)Participants must be able to hear well
enough to understand ordinary spoken conversation when the clinical specialist holds a
paper in front of his or her face to prevent the participant from lip-reading.

F)Participants must be willing to commit to the time requirements of the study and not
have any scheduled trips or absences for more than 1 week during the training.

Exclusion Criteria:

A)Participants must not be planning to begin cholinesterase inhibitor (AChEI) therapy or
to change their dosing levels. Subjects currently using AChEI will be included if they
have an established steady dosing history at least one month prior to the study and are
expected to continue at the same dosage throughout the study.

B)Participants must not have had a head trauma that caused them to lose consciousness in
the past five years and have had no subsequent symptoms.

C)Participants must not have had a stroke within the past year; or have had a stroke that
has left them with expressive or receptive language problems.

D)Participants must not have any central nervous system disorder that could contribute to
cognitive impairment.

E)Participants must not have a tremor preventing the use of a computer mouse or other
pointing device.

F)Participants must not currently be active in another clinical trial.