A Case-Referent Study of Brain Tumors in Adults
| Status: | Completed |
|---|---|
| Conditions: | Brain Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - 90 |
| Updated: | 4/17/2018 |
| Start Date: | August 19, 1994 |
| End Date: | February 26, 2018 |
The etiology of brain tumors is poorly understood. Due, in part, to public concern about a
postulated relationship between the use of cellular telephones or other increasingly
prevalent environmental exposures and the incidence of brain cancer in adults, the National
Cancer Institute is collaborating with three U.S. hospitals in a comprehensive case-control
study of malignant and benign brain tumors. Factors under consideration include use of
cellular phones and other wireless communication devices, workplace exposures to chemical
agents and electromagnetic fields, dietary factors, family history of tumors, genetic
determinants of susceptibility, home appliance use, reproductive history and hormonal
exposures, viruses, medical and dental exposure to ionizing radiation, and other aspects of
medical history.
Approximately 800 newly diagnosed brain tumor cases and 800 controls have been enrolled at
hospitals in Boston, Phoenix and Pittsburgh. Cases include all adults (age greater than or
equal to 18 years) newly diagnosed with a histologically confirmed intracranial glioma,
intracranial meningioma or acoustic neuroma. Controls are patients admitted to the same
hospitals as the cases, and treated for any of a variety of non-malignant conditions.
Participating cases and controls were interviewed in the hospital by a research nurse and
asked to complete a self-administered questionnaire and donate a sample of blood. Key
features of the study include its large size, the emphasis on rapid ascertainment of incident
cases and interview of study subjects rather than surrogate respondents, the use of detailed,
job-specific questions developed by industrial hygienists to ascertain occupational
exposures, and the storage of blood samples for future evaluation of inherited
susceptibility, biomarkers of exposure and gene-environment interactions.
Implementation of the study protocol proceeded without serious problems. There have been no
harmful effects on study participants. There have been no complaints from participants or
breaches of confidentiality. Continuation of this research involves analysis and reporting of
results. As there will be many papers, this process is expected to extend over the next
several years.
postulated relationship between the use of cellular telephones or other increasingly
prevalent environmental exposures and the incidence of brain cancer in adults, the National
Cancer Institute is collaborating with three U.S. hospitals in a comprehensive case-control
study of malignant and benign brain tumors. Factors under consideration include use of
cellular phones and other wireless communication devices, workplace exposures to chemical
agents and electromagnetic fields, dietary factors, family history of tumors, genetic
determinants of susceptibility, home appliance use, reproductive history and hormonal
exposures, viruses, medical and dental exposure to ionizing radiation, and other aspects of
medical history.
Approximately 800 newly diagnosed brain tumor cases and 800 controls have been enrolled at
hospitals in Boston, Phoenix and Pittsburgh. Cases include all adults (age greater than or
equal to 18 years) newly diagnosed with a histologically confirmed intracranial glioma,
intracranial meningioma or acoustic neuroma. Controls are patients admitted to the same
hospitals as the cases, and treated for any of a variety of non-malignant conditions.
Participating cases and controls were interviewed in the hospital by a research nurse and
asked to complete a self-administered questionnaire and donate a sample of blood. Key
features of the study include its large size, the emphasis on rapid ascertainment of incident
cases and interview of study subjects rather than surrogate respondents, the use of detailed,
job-specific questions developed by industrial hygienists to ascertain occupational
exposures, and the storage of blood samples for future evaluation of inherited
susceptibility, biomarkers of exposure and gene-environment interactions.
Implementation of the study protocol proceeded without serious problems. There have been no
harmful effects on study participants. There have been no complaints from participants or
breaches of confidentiality. Continuation of this research involves analysis and reporting of
results. As there will be many papers, this process is expected to extend over the next
several years.
The etiology of brain tumors is poorly understood. Due, in part, to public concern about a
postulated relationship between the use of cellular telephones or other increasingly
prevalent environmental exposures and the incidence of brain cancer in adults. The National
Cancer Institute is collaborating with three US hospitals in a comprehensive case-control
study of malignant and benign brain tumors. Factors under consideration include the use of
cellular phones and other wireless communication devices, workplace exposures to chemical
agents and electromagnetic fields, dietary factors, family history of tumors, genetic
determinants of susceptibility, home appliance use, reproductive history and hormonal
exposures, viruses, medical and dental exposures to ionizing radiation, and other aspects of
medical history.
Approximately 800 newly diagnosed brain tumor cases and 800 controls have been enrolled at
hospitals in Boston, Phoenix, and Pittsburgh. Cases include all adults (age age greater than
or equal to 18 years) newly diagnosed with a histologically confirmed intracranial giloma,
intracranial meningioma or acoustic neuroma. Controls are patients admitted to the same
hospitals as the cases, and treated for any of a variety of non-malignant conditions.
Participating cases and controls were interviewed in the hospital by a research nurse and
asked to complete a self-administered questionnaire and donate a sample of blood. Key
features of the study include its large size, the emphasis on rapid ascertainment of incident
cases and interview of study subjects rather than surrogate respondents, the use of detailed,
job-specific questions developed by industrial hygienists to ascertain occupational exposures
and gene-environment interactions.
Implementation of the study protocol proceeded without serious problems. There have been no
harmful effects on study participants. There have been no complaints from participants or
breaches of confidentiality. Continuation of this research involves analysis and reporting of
results. Numerous publications have resulted from the study and analyses are ongoing.
postulated relationship between the use of cellular telephones or other increasingly
prevalent environmental exposures and the incidence of brain cancer in adults. The National
Cancer Institute is collaborating with three US hospitals in a comprehensive case-control
study of malignant and benign brain tumors. Factors under consideration include the use of
cellular phones and other wireless communication devices, workplace exposures to chemical
agents and electromagnetic fields, dietary factors, family history of tumors, genetic
determinants of susceptibility, home appliance use, reproductive history and hormonal
exposures, viruses, medical and dental exposures to ionizing radiation, and other aspects of
medical history.
Approximately 800 newly diagnosed brain tumor cases and 800 controls have been enrolled at
hospitals in Boston, Phoenix, and Pittsburgh. Cases include all adults (age age greater than
or equal to 18 years) newly diagnosed with a histologically confirmed intracranial giloma,
intracranial meningioma or acoustic neuroma. Controls are patients admitted to the same
hospitals as the cases, and treated for any of a variety of non-malignant conditions.
Participating cases and controls were interviewed in the hospital by a research nurse and
asked to complete a self-administered questionnaire and donate a sample of blood. Key
features of the study include its large size, the emphasis on rapid ascertainment of incident
cases and interview of study subjects rather than surrogate respondents, the use of detailed,
job-specific questions developed by industrial hygienists to ascertain occupational exposures
and gene-environment interactions.
Implementation of the study protocol proceeded without serious problems. There have been no
harmful effects on study participants. There have been no complaints from participants or
breaches of confidentiality. Continuation of this research involves analysis and reporting of
results. Numerous publications have resulted from the study and analyses are ongoing.
- INCLUSION CRITERIA:
Age greater than or equal to 18 years.
Subjects with malignant and benign adult brain tumors from hospitals in Boston, Phoenix and
Pittsburgh.
INCLUSION CRITERIA - Controls:
Patients admitted to the same hospitals as the cases, and treated for any of a variety of
non-malignant conditions.
EXCLUSION CRITERIA:
Reasons for exclusion of cases included absense of histologic confirmation or ineligible
diagnosis (e.g., schwannoma of facial or trigeminal nerve rather than of acoustic nerve).
EXCLUSION CRITERIA - Controls:
Controls were excluded if cancer was responsible for the hospital admission.
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