HLA and KIR Associations With Infectious Viral Agents in an HIV Cohort of Women (WIHS)
| Status: | Completed |
|---|---|
| Conditions: | HIV / AIDS |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 4/21/2016 |
| Start Date: | July 2002 |
| End Date: | August 2010 |
Since the beginning of the HIV/AIDS epidemic, the number of women infected with HIV has
rapidly increased and is continuing to climb. The Women's Interagency HIV Study is being
conducted in several cities in the United States to learn more about how HIV affects women's
lives and bodies. It will examine the role of HLA and killer immunoglobulin-like receptors
(KIR) in HIV and related infections in HIV-positive and HIV-negative women. The study will
determine the relationship between KIR and HLA genes and the following: the risk of HIV
infection; HIV levels in the blood; incidence of AIDS; response to highly active
antiretroviral therapy (HAART); and response to immunotherapy.
Approximately 3,700 women will participate. Participants will visit the clinic every 6
months for 4 years. An HIV test will be given each time to HIV-negative women. A
questionnaire will also be administered. A physical examination and gynecological
examination will be given. Blood, vaginal swabs, and urine will be collected for testing. A
biological impedance test will determine any changes in weight, waist-to-hip ratios, and
breast and total body fat. Low CD4 counts and hospitalizations for HIV are to be
self-reported to study staff.
rapidly increased and is continuing to climb. The Women's Interagency HIV Study is being
conducted in several cities in the United States to learn more about how HIV affects women's
lives and bodies. It will examine the role of HLA and killer immunoglobulin-like receptors
(KIR) in HIV and related infections in HIV-positive and HIV-negative women. The study will
determine the relationship between KIR and HLA genes and the following: the risk of HIV
infection; HIV levels in the blood; incidence of AIDS; response to highly active
antiretroviral therapy (HAART); and response to immunotherapy.
Approximately 3,700 women will participate. Participants will visit the clinic every 6
months for 4 years. An HIV test will be given each time to HIV-negative women. A
questionnaire will also be administered. A physical examination and gynecological
examination will be given. Blood, vaginal swabs, and urine will be collected for testing. A
biological impedance test will determine any changes in weight, waist-to-hip ratios, and
breast and total body fat. Low CD4 counts and hospitalizations for HIV are to be
self-reported to study staff.
The aim of the study is to examine the role of HLA and killer immunolobulin-like receptors
(KIR) in the natural history of HPV, HCV, and HBV in HIV-positive and HIV-negative women.
The immune response to viral infection mediated by T lymphocytes is HLA restricted,
suggesting that HLA class I, and class II might be associated with risk of viral infection,
persistence and disease progression. Natural killer (NK) cells are a unique group of
lymphocytes involved in surveillance and killing of foreign or infected cells through a
mechanism involving recognition of HLA molecules by an extremely diverse set of receptors on
the NK cell surface. A major group of these receptors are the KIRs. Thus, a relationship
between KIR genotype and HIV infection is biologically plausible, and requires further
investigation in observational studies.
The WIHS study is a prospective study, which may allow us to answer questions relating to
the role of host HLA and KIR genotype on duration of infection, and the development of
virus-associated diseases such as cervical cancer (related to HPV infection), and liver
cancer (HBV and HCV). WIHS is a large, racially and geographically diverse cohort of HIV
positive (n = 2761), and risk-matched HIV-negative women (n = 942). The large size of the
cohort will provide substantial statistical power, which is of major importance in any HLA
association study.
(KIR) in the natural history of HPV, HCV, and HBV in HIV-positive and HIV-negative women.
The immune response to viral infection mediated by T lymphocytes is HLA restricted,
suggesting that HLA class I, and class II might be associated with risk of viral infection,
persistence and disease progression. Natural killer (NK) cells are a unique group of
lymphocytes involved in surveillance and killing of foreign or infected cells through a
mechanism involving recognition of HLA molecules by an extremely diverse set of receptors on
the NK cell surface. A major group of these receptors are the KIRs. Thus, a relationship
between KIR genotype and HIV infection is biologically plausible, and requires further
investigation in observational studies.
The WIHS study is a prospective study, which may allow us to answer questions relating to
the role of host HLA and KIR genotype on duration of infection, and the development of
virus-associated diseases such as cervical cancer (related to HPV infection), and liver
cancer (HBV and HCV). WIHS is a large, racially and geographically diverse cohort of HIV
positive (n = 2761), and risk-matched HIV-negative women (n = 942). The large size of the
cohort will provide substantial statistical power, which is of major importance in any HLA
association study.
- INCLUSION CRITERIA:
DNA and relevant clinical data from properly consented WIHS subjects (maximum estimated at
3500) will be provided to our lab for genotyping and analysis.
EXCLUSION CRITERIA:
No available subjects will be excluded.
We found this trial at
1
site
9609 Medical Center Drive
Bethesda, Maryland 20892
Bethesda, Maryland 20892
1-800-422-6237
National Cancer Institute , 9000 Rockville Pike The National Cancer Institute (NCI) is part of...
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