BEST (Burn Center Evaluation of Standard Therapies) Ventilator Mode Study-
| Status: | Terminated |
|---|---|
| Conditions: | Other Indications, Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | July 2006 |
| End Date: | February 2010 |
BEST (Burn Center Evaluation of Standard Therapies) Ventilator Mode Study: A Prospective Randomized Controlled Trial
The purpose of this study is to compare High Frequency Pressure Ventilation (HFPV) to
conventional mechanical ventilation.
Hypothesis: Patients placed on HFPV will have significantly higher number of ventilator-free
days compared to patients placed on a conventional volume mode.
conventional mechanical ventilation.
Hypothesis: Patients placed on HFPV will have significantly higher number of ventilator-free
days compared to patients placed on a conventional volume mode.
This is a prospective, randomized, controlled trial comparing HFPV to conventional
ventilator modes in the support of burn patients with respiratory failure. Burn patients who
develop the need for mechanical ventilation present a variety of challenges that call for
innovative therapeutic options. Even in the absence of smoke inhalation injury,decreased
chest wall compliance from full thickness burns as well as massive fluid requirements are
just a few variables that make it difficult to achieve gas exchange goals when attempting to
apply conventional lung protective strategies recommended by the ARDS Net investigators.
ventilator modes in the support of burn patients with respiratory failure. Burn patients who
develop the need for mechanical ventilation present a variety of challenges that call for
innovative therapeutic options. Even in the absence of smoke inhalation injury,decreased
chest wall compliance from full thickness burns as well as massive fluid requirements are
just a few variables that make it difficult to achieve gas exchange goals when attempting to
apply conventional lung protective strategies recommended by the ARDS Net investigators.
Inclusion Criteria:
- Patients who are deemed to require ventilatory support for more than 24 hours from
the time of screening.
Exclusion Criteria:
- Anticipated extubation within 24 hours of screening
- Patients who are pregnant Patients not expected to survive for more than 24 hours
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