A Phase II Open Label Study of BMS-582664 in Locally Advanced or Metastatic Hepatocellular Cancer

Inclusion Criteria:

- Diagnosis of hepatocellular carcinoma (HCC) ≥ 2cm based on:

- Biopsy OR

- Radiological evidence of HCC by contrast-enhanced CT scan or contrast-enhanced AND

- Blood test positive for Hepatitis B or C AND

- Alpha fetoprotein above > 400 mg/L

- Not appropriate for curative surgery

- Screening Blood Pressure <150/100 mmHg, Left Ventricular Ejection Fraction (LVEF)
>50%

Exclusion Criteria:

- Heart Attack within 12 months, uncontrolled chest pain within 6 months

- Ascites resistant to diuretic medication therapy

- Portal-systemic encephalopathy

- Portal hypertension with bleeding esophageal or gastric varices within the past 2
months

- Deficiency of sodium in the blood with sodium < 125 mEq/L

- Subjects with serious non-healing wounds, ulcers or bone fractures