Palifermin in Lessening Oral Mucositis in Patients Undergoing Radiation Therapy and Chemotherapy for Locally Advanced Head and Neck Cancer

OBJECTIVES:

Primary

- Compare the efficacy of palifermin vs placebo, in terms of burden of acute mucositis
(defined to be 105 days [15 weeks] or less from the start of treatment), in patients
with squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx
undergoing concurrent radiotherapy and chemotherapy.

Secondary

- Compare incidence and time to onset of Grades 3 or 4 oral mucositis in patients treated
with these regimens.

- Compare overall and progression-free survival and time to second primary in patients
treated with these regimens.

OUTLINE: This is a randomized, double-blind, placebo-controlled, multicenter study. Patients
are stratified according to disease stage (III vs IVA or IVB), tumor site (oral cavity or
oropharynx vs hypopharynx or larynx), and radiotherapy technique used on study
(intensity-modulated radiotherapy [IMRT] vs 3-dimensional conformal radiotherapy [3D-CRT]).
Patients are randomized to 1 of 2 treatment arms.

Mucositis, pain, and symptom burden are assessed at baseline, during radiotherapy, and post
radiotherapy. Xerostomia is assessed at baseline, during radiotherapy, and several times
after completion of study therapy.

After completion of study therapy, patients are followed periodically for 10 years.

PROJECTED ACCRUAL: A total of 298 patients will be accrued for this study.

Inclusion Criteria:

1. Pathologically (histologically or cytologically) proven (from primary lesion and/or
lymph nodes) diagnosis of squamous cell carcinoma of the oral cavity, oropharynx,
hypopharynx, or larynx;

2. Patients must have at least 2 mucosal sites of the oral cavity/oropharynx mucosa
assessable by visual transoral inspection that will receive at least 66 Gy;

-2.1 Patients with tumors of the larynx or hypolarynx are eligible only if it is
anticipated that the 2 index sites in the oral cavity/oropharynx mucosa will receive
at least 66 Gy;

3. Patients must be able to be evaluated for the primary endpoint; therefore, patients
must be able to eat at least soft solids and not require a feeding tube for nutrition
or hydration at study entry.

4. Selected Stage III (excluding T1N1MO) or IVA-B (AJCC, 6th edition) at study entry,
including no distant metastases, based upon the following minimum diagnostic workup:

- 4.1 History/physical examination, including documentation of tobacco/alcohol use
and current medications (including opioids/dosing), within 8 weeks prior to
registration;

- 4.2 Chest x-ray (or Chest CT scan) within 6 weeks prior to registration;

- 4.3 MRI or CT scan with contrast of tumor site within 6 weeks prior to
registration;

- 4.4 Assessment of mucositis and xerostomia within 2 weeks prior to registration;

5. Zubrod Performance Status 0-1;

6. Age > 18;

7. Adequate bone marrow function, defined as follows:

- 7.1 Absolute neutrophil count (ANC) > 1,800 cells/mm3 based upon CBC/differential
obtained within 2 weeks prior to registration on study

- 7.2 Platelets > 100,000 cells/mm3 based upon CBC/differential obtained within 2
weeks prior to registration on study

- 7.3 Hemoglobin > 8.0 g/dl based upon CBC/differential obtained within 2 weeks
prior to registration on study (Note: The use of transfusion or other
intervention to achieve Hgb > 8.0 g/dl is acceptable.)

8. Adequate hepatic function with bilirubin < 1.5 mg/dl, AST or ALT < 2 x ULN within 2
weeks prior to registration;

9. Adequate renal function with serum creatinine < 1.5 mg/dl and creatinine clearance
(CC) ≥ 50 ml/min within 2 weeks prior to registration determined by 24-hour collection
or estimated by Cockcroft-Gault formula:

CCr male = [(140 - age) x (wt in kg)]/[(Serum Cr mg/dl) x (72)] CCr female = 0.85 x
(CrCl male)

10. Normal serum calcium or normal corrected serum calcium within 2 weeks prior to
registration; formula for corrected calcium if albumin valued is below normal range:
Corrected calcium (mg/dl) = (4 - [patient's albumin (g/dl)] x 0.8) + patient's
measured calcium (mg/dl);

11. Serum pregnancy test for women of childbearing potential within 2 weeks prior to
registration;

12. Women of childbearing potential and male participants must practice adequate
contraception.

13. Patient agrees to refrain from using all products listed in Section 9.2,
"Non-permitted Supportive Therapy";

14. Patient must sign study specific informed consent prior to study entry.

Exclusion Criteria:

1. Patients with a history of prior head and neck squamous cancer are ineligible;

2. Stage IVC (AJCC, 6th edition) [Any T, Any N, M1] or distant metastases at protocol
study entry; T1N1M0 patients are excluded.

3. Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free
for a minimum of 3 years;

4. Prior systemic chemotherapy for the study cancer; note that prior chemotherapy for a
different cancer is allowable. See Sections 1 and 3.

5. Prior radiotherapy to the region of the study cancer that would result in overlap of
radiation therapy fields;

6. Initial surgical treatment, excluding diagnostic biopsy of the primary site or nodal
sampling of neck disease; radical or modified neck dissection is not permitted.

7. Severe, active co-morbidity, defined as follows:

- 7.1 Symptomatic and/or uncontrolled cardiac disease, New York Heart Association
Classification III or IV (see Appendix II);

- 7.2 Transmural myocardial infarction within the last 6 months;

- 7.3 Acute bacterial or fungal infection requiring intravenous antibiotics at the
time of registration;

- 7.4 Chronic Obstructive Pulmonary Disease exacerbation or other respiratory
illness requiring hospitalization or precluding study therapy at the time of
registration.

- 7.5 Hepatic insufficiency resulting in clinical jaundice and/or coagulation
defects;

- 7.6 Patients known to be sero-positive for hepatitis B virus (HBV) or hepatitis C
virus (HCV);

- 7.7 Patients known to be sero-positive for human immunodeficiency virus (HIV) or
patients with Acquired Immune Deficiency Syndrome (AIDS) based upon current CDC
definition; note, however, that HIV testing is not required for entry into this
protocol. The need to exclude patients with HIV or AIDS from this protocol is
necessary because the treatments involved in this protocol may be significantly
immunosuppressive.

- 7.8 A history of pancreatitis.

8. Collagen vascular disease, such as scleroderma, as this disease is thought to
predispose patients to increased risk for radiation-associated toxicities;

9. Previous treatment with palifermin or other keratinocyte growth factors, such as
velafermin or repifermin;

10. Prior allergic reaction or known sensitivity to any of the agents administered during
dosing, including E. coli-derived products, such as Nutropin®, Neupogen®, Humulin®,
Roferon®; Neumega®, Neulasta®), IntronA®, Betaseron®;

11. Pregnancy or women of childbearing potential and men who are sexually active and not
willing/able to use medically acceptable forms of contraception; this exclusion is
necessary because the treatment involved in this study may be significantly
teratogenic.