Effect of Eszopiclone on Sleep Disturbance and Pain in Cancer
| Status: | Completed |
|---|---|
| Conditions: | Insomnia Sleep Studies |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 20 - 75 |
| Updated: | 4/21/2016 |
| Start Date: | September 2006 |
| End Date: | December 2009 |
Effect of Eszopiclone (Lunesta) on Sleep Disturbance and Pain in Cancer
To assess the effectiveness of Lunesta on cancer patients who have received chemotherapy and
who require patient controlled analgesia (PCA), specifically to assess whether Lunesta will:
- improve sleep thereby decreasing need for opiates via PCA
- improve sleep thereby decreasing pain by self report
- improve sleep thereby decreasing fatigue by self report
who require patient controlled analgesia (PCA), specifically to assess whether Lunesta will:
- improve sleep thereby decreasing need for opiates via PCA
- improve sleep thereby decreasing pain by self report
- improve sleep thereby decreasing fatigue by self report
Pain and fatigue are the most common symptom complaints of cancer patients. Although
dramatic improvements have come about in recognizing and treating cancer related pain, less
progress has been made in treating fatigue. Interventions to improve sleep may offer benefit
in terms of pain and fatigue.
One of the less commonly recognized side effects of opiate use is sleep disruption.
Experimentally-induced sleep disruption lowers the threshold for detection of painful
stimuli. Thus, although opiates are obviously helpful for pain, they do so at certain
"costs": they increase next day fatigue, constipation, and have other side effects; they
disrupt sleep which further increases next day fatigue; and finally, by virtue of their
sleep disruptive properties, they lower the threshold for pain stimuli.
Cancer patients requiring chemotherapy commonly require PCA because of oral mucositis. The
objective of this study is to assess whether opiate usage may be reduced and complaints of
fatigue and pain be lessened if patients had better sleep.
dramatic improvements have come about in recognizing and treating cancer related pain, less
progress has been made in treating fatigue. Interventions to improve sleep may offer benefit
in terms of pain and fatigue.
One of the less commonly recognized side effects of opiate use is sleep disruption.
Experimentally-induced sleep disruption lowers the threshold for detection of painful
stimuli. Thus, although opiates are obviously helpful for pain, they do so at certain
"costs": they increase next day fatigue, constipation, and have other side effects; they
disrupt sleep which further increases next day fatigue; and finally, by virtue of their
sleep disruptive properties, they lower the threshold for pain stimuli.
Cancer patients requiring chemotherapy commonly require PCA because of oral mucositis. The
objective of this study is to assess whether opiate usage may be reduced and complaints of
fatigue and pain be lessened if patients had better sleep.
Inclusion Criteria:
1. Male or female patients hospitalized for chemotherapy or blood/bone marrow
transplant.
2. Age 20 - 75
3. Not currently regularly taking any prescribed sleeping pill more often than 4x/week.
4. Can tolerate oral medication.
Exclusion Criteria:
1. Patients with a current history of substance abuse
2. Patients with a history of allergic response to Lunesta.
3. Patient who require additional oral or parenteral opioids after starting PCA opioid
treatment.
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