Study of Apixaban for the Prevention of Thrombosis-related Events Following Knee Replacement Surgery
| Status: | Completed |
|---|---|
| Conditions: | Cardiology, Cardiology, Cardiology, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | November 2006 |
| End Date: | May 2008 |
A Phase 3 Randomized, Double-Blind Active-Controlled (Enoxaparin), Parallel-Group, Multi-Center Study to Evaluate the Safety and Efficacy of Oral Apixaban in Subjects Undergoing Elective Total Knee Replacement Surgery
The purpose of this study is to learn if apixaban can prevent blood clots in the leg (deep
vein Thrombosis [DVT]) and lung (pulmonary embolism [PE]) that sometimes occur after knee
replacement surgery and to learn how apixaban compares to enoxaparin (Lovenox®) for
preventing these clots. The safety of apixaban will also be studied.
vein Thrombosis [DVT]) and lung (pulmonary embolism [PE]) that sometimes occur after knee
replacement surgery and to learn how apixaban compares to enoxaparin (Lovenox®) for
preventing these clots. The safety of apixaban will also be studied.
Key Inclusion Criteria:
- Men and non-pregnant, non-breastfeeding women
- 18 years or older
- Scheduled for knee replacement surgery
Key Exclusion Criteria:
- hereditary or acquired bleeding disorders
- clotting disorders
- bleeding or high risk for bleeding
- drugs that affect bleeding or coagulation
- need for ongoing parenteral or oral anticoagulation
We found this trial at
25
sites
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