Soft Tissue Biomechanical Behavior During Acupuncture in Low Back Pain



Status:Completed
Conditions:Back Pain
Therapuetic Areas:Musculoskeletal
Healthy:No
Age Range:21 - 55
Updated:11/23/2013
Start Date:September 2006
End Date:September 2009
Contact:Debbie J Stevens-Tuttle, B.A.
Email:debbie.stevens-tuttle@uvm.edu
Phone:802-656-5552

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The goal of this proposal is to test the overall hypothesis that subjects with chronic or
recurrent low back pain have an abnormal soft tissue response to acupuncture needling, and
that this altered response is associated with abnormal perimuscular connective tissue
structure and biomechanics. We will also test whether or not altered needling responses in
low back pain are generalized, or localized to specific locations as predicted by
traditional acupuncture theory. This proposal is part of a series of projects investigating
the role of connective tissue in the mechanism of acupuncture and, in addition, constitutes
a first step in examining the role of connective tissue in low back pain. Acupuncturists
describe qualitatively different needling responses at locations believed to be "involved"
in the patient's disease process. Although assessing abnormalities in the needling response
is a fundamental aspect of acupuncture therapy, what constitutes a normal vs. abnormal
needling response has never been studied quantitatively. Thus the nature of tissue changes
underlying these phenomena remains unknown. We have recently developed a new in vivo
technique based on ultrasound elastography that allows visualization and quantification of
tissue displacement and strain patterns developed in tissues during needle manipulation in
humans [1] (Appendix A). In this proposal, we will use ultrasound elastography, ultrasound
image analysis and biomechanical modeling to perform 1) quantitative measurement of soft
tissue behavior during needling and 2) detailed analysis of perimuscular connective tissue
structure and biomechanics in human subjects with and without low back pain.


See Brief Summary

Inclusion Criteria:

Inclusion criteria for LBP subjects will be the following:

1. History of recurrent or chronic LBP as defined by Von Korff {Von Korff, 1992 #6777}
{Von Korff, 1994 #6816} for a minimum of 12 months

2. Able to stand and walk without assistance

3. Able to understand and read English

4. Able to understand and sign a consent form. Subjects' LBP will be further defined as
being recurrent or chronic LPB based on the number of days with symptoms over a
period of one year.

- Recurrent LBP will be defined as back pain present on less than ½ the days in a
12-month period, occurring in multiple episodes over a year.

- Chronic LBP will be defined as back pain present on at least ½ the days in a
12-month period in a single or multiple episodes.

Inclusion criteria for No-LBP subjects:

Criteria for selecting No-LBP subjects will be:

1. No history of low back pain or any other chronic pain that has limited activities of
daily living or work

2. A numerical current pain index of less than 0.5. No-LBP subjects will be matched for
age, sex and subcutaneous tissue thickness with LBP subjects.

Exclusion Criteria:

For all subjects, exclusion criteria determined by history and physical exam will be the
following:

1. Previous severe back or low extremity injury or surgery

2. Major structural spinal deformity (scoliosis, kyphosis, stenosis)

3. Ankylosing spondylitis or rheumatoid arthritis

4. Spondyloarthropathy or disc herniation

5. Spinal fracture, tumor or infection

6. Neurological deficit (weakness and/or sensory loss, decreased deep tendon reflexes
suggesting nerve root compression, but not subjective symptoms of nerve root
irritation (sciatica)

7. Neurological or major psychiatric disorder

8. Bleeding disorders

9. Corticosteroid or anticoagulant medication

10. Pregnancy

11. worker's compensation or disability case

12. In litigation for the LBP problem

13. Acute systemic infection

14. BMI greater than 23% or less than 32%. Preliminary testing has shown that
individuals with a BMI of less than 23% have an insufficient depth of the
subcutaneous and fat zone (Zone P) for data processing. Individuals with a BMI
greater than 32% have a subcutaneous and fat zone (Zone P) thickness which is greater
than the acupuncture needle length, which will not allow penetration of the muscle
layer (Zone M).

15. Subjects will need to not take non-steroidal anti-inflammatory (NSAIDs) medication
for 3 days prior to testing in order to avoid the potentially confounding acute
effects of NSAIDs on connective tissue.

16. In addition, LBP subjects will be excluded if they are in an acute flare-up of LBP.
Flare-up will be defined as short period (less than one week) when pain is markedly
more severe than usual for that individual (at least 5 points above baseline on pain
index).
We found this trial at
1
site
85 S Prospect St
Burlington, Vermont 5405
(802) 656-3131
University of Vermont The University of Vermont combines faculty-student relationships most commonly found in a...
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from
Burlington, VT
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