A Study of the Safety and Efficacy of CNTO 328 and Bortezomib to Bortezomib Alone in Patients With Relapsed or Refractory Multiple Myeloma

The purpose of this study is to see what effects CNTO 328 has on relapsed or refractory
multiple myeloma. The study drug, CNTO 328, is a chimeric (part mouse) antibody (small
protein that is important for fighting infection).CNTO 328 blocks a small protein called
Interleukin 6 (IL-6). IL-6 is made naturally by your body, and at normal levels is important
for inflammatory response. High levels of IL-6 can help cancer cells grow and interfere with
chemotherapy drugs killing cancer cells. Cancer-related sickness such as cachexia (weight
loss), bone resorption (weakening of your bones), and depression have been linked to high
levels of IL-6. CNTO 328 has been shown to slow down tumor growth or shrink tumors when
tested in animals. In other clinical trials, over 100 patients have received CNTO 328. There
are studies ongoing in participants with kidney cancer, hematologic malignancies (blood
cancers such as multiple myeloma), and prostate cancer, to see if CNTO 328 is safe and to see
what effects it has on these types of cancer. At this time, it is unknown what effect CNTO
328 has had on the participants' cancer. Bortezomib is a type of drug known as a "proteasome
inhibitor." A proteasome is a substance that is found in every cell and it is there to help
to break down other substances ('proteins') and has a role in the way cells divide. If the
proteasome is inhibited, it cannot perform its function in the cell, and if a cell cannot
divide it dies. Over 8000 patients with multiple myeloma and other types of cancer have been
treated with bortezomib. Bortezomib has been extensively studied in patients with previously
treated multiple myeloma. Based on its established activity in pretreated multiple myeloma,
bortezomib is registered in the United States and in Europe for the treatment of multiple
myeloma patients who have received at least two prior therapies and have demonstrated disease
progression on the last therapy. Bortezomib is currently also being studied in several other
cancer types.This study consists of two parts. The purpose of Part 1 is to determine the
safety of CNTO 328 and bortezomib when given together as a treatment. The purpose of Part 2
is to compare the safety and effects (good and bad) of the combination of CNTO 328 and
bortezomib to the safety and effects of bortezomib alone. About 20 patients will take part in
the first part of the study. About 270 patients will take part in the second part of the
study at approximately 70 sites in the US, Canada, and Europe. Patients will be in the study
for about 12 months, with a follow-up period of around 9 months. The study is divided into
four different phases: Screening phase-which lasts up to 4 weeks. During this phase the study
doctor will perform tests to see if the patient can participate in the study.Treatment
phase-which may last up to 4 cycles of 42 days each during which the patient will be treated
with CNTO 328 and bortezomib. Maintenance phase-If the patient benefits from the therapy in
the treatment phase, the patient will continue to receive CNTO 328 and bortezomib, but now in
cycles of 35 days each. Follow up phase, this includes an end of treatment visit 4 weeks
after the patient's last infusion and follow up visits every three months until the patient
starts a new anti-cancer treatment. CNTO 328 6mg/kg ( 6 milligrams per kilogram of body
weight) will be given intravenously (into the vein) over 2 hours once every 2 weeks. Patients
who respond with stable disease or better may receive additional doses. Bortezomib will be
given IV (into the vein) at 1.3 mg/m2 over 3-5 seconds twice a week for 2 weeks followed by 1
week of rest.

Inclusion Criteria:

- Measurable secretory disease defined as either serum monoclonal paraprotein,
(M-protein) greater than or equal to (>=)1 gram per deciliter (g/dL) or urine
monoclonal (light chain) protein (> 200 mg/24 hours)

- Documented disease progression after at least 1 prior line of therapy but no more than
3 or have had no response to previous treatment (primary refractory disease)

- ECOG performance status score of less than or equal to (<=) 2

- Adequate bone marrow, liver, and renal function

Exclusion Criteria:

- No prior treatment with bortezomib

- Not Refractory to high-dose dexamethasone

- Not >= Grade 2 peripheral neuropathy

- Have not received an allogeneic bone marrow or allogeneic peripheral blood stem cell
transplant

- No prior or concomitant malignancy (other than multiple myeloma) except adequately
treated basal cell or squamous cell carcinoma of the skin, carcinoma in situ of the
cervix, or other cancer for which the patient has been disease-free for <= 3 years