An Efficacy Study Comparing ZD6474 to Placebo in Medullary Thyroid Cancer
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Cancer, Cancer, Endocrine, Thyroid Cancer |
| Therapuetic Areas: | Endocrinology, Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/13/2018 |
| Start Date: | November 30, 2006 |
| End Date: | December 31, 2019 |
An International, Phase III, Randomized, Double-Blinded, Placebo-Controlled, Multi-Center Study to Assess the Efficacy of ZD6474 (ZACTIMATM) Versus Placebo in Subjects With Unresectable Locally Advanced or Metastatic Medullary Thyroid Cancer
The purpose of this study is to learn how hereditary or sporadic medullary thyroid cancer
patients, treated with ZD6474, react to the drug, what happens to ZD6474 in the human body,
about the side effects of ZD6474, and if ZD6474 can decrease or prevent the growth of tumors.
patients, treated with ZD6474, react to the drug, what happens to ZD6474 in the human body,
about the side effects of ZD6474, and if ZD6474 can decrease or prevent the growth of tumors.
Inclusion Criteria:
- Confirmed diagnosis of unresectable, locally advanced or metastatic hereditary or
sporadic Medullary Thyroid Cancer.
- Presence of measurable tumor
- Able to swallow medication
Exclusion Criteria:
- Major surgery within 4 weeks before randomization
- Last dose of prior chemotherapy received less than 4 weeks prior to randomization
- Radiation therapy within the last 4 weeks prior to randomization(with exception of
palliative radiotherapy)
- Brain metastases or spinal cord compression, unless treated at least 4 weeks before
first dose and stable without steroid treatment for 10 days
- Significant cardiac events
- Previous ZD6474 treatment
We found this trial at
17
sites
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