Project to Investigate Ways to Reduce the Spread of Influenza in Schools and Households With Children
| Status: | Completed |
|---|---|
| Conditions: | Influenza |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 4/21/2016 |
| Start Date: | January 2007 |
| End Date: | September 2009 |
Pittsburgh Influenza Prevention Project
The purpose of this study is to understand the spread of influenza (flu) in schools and
households with elementary (K-5) school children, and develop ways to reduce the flu using
non-pharmaceutical means.
households with elementary (K-5) school children, and develop ways to reduce the flu using
non-pharmaceutical means.
Pandemic influenza threatens to cause substantial disability, death, and societal disruption
and to overwhelm health care systems in the United States and around the world. Because
effective vaccines may not be available during the initial months of a pandemic, and because
anti-viral medication is both largely ineffective and in short supply, non-pharmacological
personal protection and behavioral changes may be the only means to combat the epidemic. In
our computational modeling work (through the Models of Infectious Disease Agent Study
network), we have shown the potential value of multiple targeted and layered
non-pharmacological interventions in blunting the peak impact and slowing of a pandemic
(Nature, in press).
Phase 1 of the project will be a pilot study in two elementary schools in the City of
Pittsburgh. The project has already obtained agreement to collaborate from the Pittsburgh
Public School System and we have assembled a multi-disciplinary team of epidemiologists,
systems analysts, modelers, community and minority health workers, and virologists to
implement the project. Phase one was in 2 schools.
Phase 2 will be similar to Phase 1 with the addition of additional schools and application
of a "hygiene" intervention to selected schools and families. Phase 2 is in 10 schools with
3800 students.
Specific aims (year 02):
Primary
1. Measure the effectiveness of non-pharmaceutical interventions (NPIs) in reducing
influenza rates among enrolled students in the intervention and control schools when
influenza is known to be circulating in the community. [Note: Enrolled, for purposes of
PIPP, will indicate students who present with ILI, consent to participate, and are
tested for influenza during the flu season.] Secondary: School-Based
2. Measure number of absentees and determine the reason for absence by using a school
based absentee illness surveillance system prior to and through the end of influenza
season.
3. Measure the effectiveness of NPIs in reducing absenteeism from all causes, including
illness/URI, illness/ILI, illness/other, and illness/GI through the end of influenza
season.
4. Measure the effectiveness of NPIs in reducing secondary spread of ILI within classrooms
of participating schools.
5. Assess adoption of NPI behaviors and activities in classrooms of intervention schools.
Secondary: Home-Based
6. Measure the effectiveness of NPIs in reducing secondary cases of ILI within families of
enrolled school children with influenza.
7. Assess adherence of families of enrolled school children with influenza to
isolation-related NPI behaviors and activities.
Tertiary
8. Measure correlation between rapid flu testing and PCR testing for influenza.
9. Collect and archive influenza specimens for future molecular epidemiological studies.
10. Contribute a sample of influenza-positive specimens to the CDC for national influenza
surveillance purposes.
and to overwhelm health care systems in the United States and around the world. Because
effective vaccines may not be available during the initial months of a pandemic, and because
anti-viral medication is both largely ineffective and in short supply, non-pharmacological
personal protection and behavioral changes may be the only means to combat the epidemic. In
our computational modeling work (through the Models of Infectious Disease Agent Study
network), we have shown the potential value of multiple targeted and layered
non-pharmacological interventions in blunting the peak impact and slowing of a pandemic
(Nature, in press).
Phase 1 of the project will be a pilot study in two elementary schools in the City of
Pittsburgh. The project has already obtained agreement to collaborate from the Pittsburgh
Public School System and we have assembled a multi-disciplinary team of epidemiologists,
systems analysts, modelers, community and minority health workers, and virologists to
implement the project. Phase one was in 2 schools.
Phase 2 will be similar to Phase 1 with the addition of additional schools and application
of a "hygiene" intervention to selected schools and families. Phase 2 is in 10 schools with
3800 students.
Specific aims (year 02):
Primary
1. Measure the effectiveness of non-pharmaceutical interventions (NPIs) in reducing
influenza rates among enrolled students in the intervention and control schools when
influenza is known to be circulating in the community. [Note: Enrolled, for purposes of
PIPP, will indicate students who present with ILI, consent to participate, and are
tested for influenza during the flu season.] Secondary: School-Based
2. Measure number of absentees and determine the reason for absence by using a school
based absentee illness surveillance system prior to and through the end of influenza
season.
3. Measure the effectiveness of NPIs in reducing absenteeism from all causes, including
illness/URI, illness/ILI, illness/other, and illness/GI through the end of influenza
season.
4. Measure the effectiveness of NPIs in reducing secondary spread of ILI within classrooms
of participating schools.
5. Assess adoption of NPI behaviors and activities in classrooms of intervention schools.
Secondary: Home-Based
6. Measure the effectiveness of NPIs in reducing secondary cases of ILI within families of
enrolled school children with influenza.
7. Assess adherence of families of enrolled school children with influenza to
isolation-related NPI behaviors and activities.
Tertiary
8. Measure correlation between rapid flu testing and PCR testing for influenza.
9. Collect and archive influenza specimens for future molecular epidemiological studies.
10. Contribute a sample of influenza-positive specimens to the CDC for national influenza
surveillance purposes.
Inclusion Criteria (student):
- Students in grades K-8 with a current influenza-like illness (ILI) during flu
season.ILI defined as an oral or aural temperature > 100 °F AND either new onset
cough or sore throat.Flu season is defined as December, 2006 through March/April,
2007.
- Parental consent and student assent.
Inclusion Criteria (household members):
- Shares living space with K-8 child who has current influenza infection.
- Parental consent and child assent in the case of minors.
- Individual consent if over the age of 18.
- Will continue in the study even if student with confirmed influenza withdraws from
the study.
Exclusion Criteria (student):
- The participant has a medical or mental health condition which in the judgment of the
investigator is a barrier to safe participation.
- The participant is unable to tolerate a swab or capillary finger stick.
- There is a delay in notification or testing such that symptoms have resolved.
Exclusion Criteria (household):
- The participant has a medical or mental health condition which in the judgment of the
investigator is a barrier to safe participation.
- The participant is younger than 6 months.
- The participant is unable to tolerate a swab or capillary finger stick.
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