Progression of Spinal Fusion in Ankylosing Spondylitis
| Status: | Recruiting |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/6/2019 |
| Start Date: | December 3, 2004 |
| Contact: | Nancy A Spencer |
| Email: | nancy.spencer@nih.gov |
| Phone: | (301) 827-0186 |
This study will evaluate: 1) whether computed tomography (CT) scanning is better than regular
x-rays for measuring changes in the stiffness, or fusion, of the spine in patients with
ankylosing spondylitis; and 2) if CT can be used to determine how fast extra bone forms in
the spine of these patients. Better ways to measure spinal fusion are needed to be able to
evaluate the effectiveness of medicines in slowing or stopping its progression. CT uses
x-rays to provide detailed pictures of the inside of the body and are valuable for detecting
spinal abnormalities because of the precision with which it can show these structures. For
the procedure, the patient lies on a table that moves into a large, donut-shaped scanner that
can move around the body to take pictures at different angles, which are viewed on a computer
monitor.
Patients 18 years of age and older with ankylosing spondylitis who are not currently taking
or planning to receive treatment with anti-TNF alpha medications (etanercept, infliximab,
adalimumab) for 1 year may be eligible for this study. Participants have eight clinic visits,
scheduled at study entry and at 4, 8, 12, 16, 20, 24, and 48 months, at the NIH Clinical
Center for the following procedures:
- Clinical assessment (all visits) - includes medical history and physical examination,
measurement of spine flexibility with a tape measure and protractor, symptoms
questionnaire
- Blood tests for measures of inflammation, including red blood cell sedimentation rate
and C-reactive protein level (all visits)
- Urine pregnancy test in women of child-bearing age (visits 1, 4, 7, 8)
- X-rays of the pelvis, low back, and neck (visits 1, 4, 7)
- X-ray of the low back (visit 8)
- CT scan of the low back (visits 1, 4, 7)
- Magnetic resonance imaging (MRI) of the low back (visits 1, 4) - MRI combines a powerful
magnet with an advanced computer system and radio waves to produce accurate, detailed
pictures of organs and tissues. The patient lies on a table in a narrow cylinder
containing a magnetic field, wearing earplugs to muffle loud noises that occur with
electrical switching of the magnetic fields. He or she can speak with a staff member via
an intercom system at all times during the procedure. During the scan, a contrast dye
(gadolinium) is injected into the bloodstream through a catheter (plastic tube inserted
in a vein) to brighten the images.
In addition, participants will complete a symptoms questionnaire by mail every 4 months for 2
years between visits 7 and 8.
x-rays for measuring changes in the stiffness, or fusion, of the spine in patients with
ankylosing spondylitis; and 2) if CT can be used to determine how fast extra bone forms in
the spine of these patients. Better ways to measure spinal fusion are needed to be able to
evaluate the effectiveness of medicines in slowing or stopping its progression. CT uses
x-rays to provide detailed pictures of the inside of the body and are valuable for detecting
spinal abnormalities because of the precision with which it can show these structures. For
the procedure, the patient lies on a table that moves into a large, donut-shaped scanner that
can move around the body to take pictures at different angles, which are viewed on a computer
monitor.
Patients 18 years of age and older with ankylosing spondylitis who are not currently taking
or planning to receive treatment with anti-TNF alpha medications (etanercept, infliximab,
adalimumab) for 1 year may be eligible for this study. Participants have eight clinic visits,
scheduled at study entry and at 4, 8, 12, 16, 20, 24, and 48 months, at the NIH Clinical
Center for the following procedures:
- Clinical assessment (all visits) - includes medical history and physical examination,
measurement of spine flexibility with a tape measure and protractor, symptoms
questionnaire
- Blood tests for measures of inflammation, including red blood cell sedimentation rate
and C-reactive protein level (all visits)
- Urine pregnancy test in women of child-bearing age (visits 1, 4, 7, 8)
- X-rays of the pelvis, low back, and neck (visits 1, 4, 7)
- X-ray of the low back (visit 8)
- CT scan of the low back (visits 1, 4, 7)
- Magnetic resonance imaging (MRI) of the low back (visits 1, 4) - MRI combines a powerful
magnet with an advanced computer system and radio waves to produce accurate, detailed
pictures of organs and tissues. The patient lies on a table in a narrow cylinder
containing a magnetic field, wearing earplugs to muffle loud noises that occur with
electrical switching of the magnetic fields. He or she can speak with a staff member via
an intercom system at all times during the procedure. During the scan, a contrast dye
(gadolinium) is injected into the bloodstream through a catheter (plastic tube inserted
in a vein) to brighten the images.
In addition, participants will complete a symptoms questionnaire by mail every 4 months for 2
years between visits 7 and 8.
Spinal fusion is the clinical, radiological, and pathological hallmark of ankylosing
spondylitis (AS). However, spinal fusion occurs slowly in AS. Serial radiographs rarely show
changes over 2 years, and often 5 or more years are needed to demonstrate progression of
spinal fusion. Methods that are more sensitive to changes in the extent of spinal fusion than
plain radiographs are needed to test if any treatments can slow or halt spinal fusion in AS.
The need for an improved measure of spinal fusion is heightened now that several new
medications are available that have the potential to markedly decrease spinal inflammation in
AS.
The goal of this pilot study is to test whether measurement of bone mineral density, bone
volume, or bone mass at the annulus fibrosis of lumbar disc spaces by computed tomography
(CT) can provide a reliable, valid, and sensitive measure of spinal fusion in patients with
AS. Fifty-five participants will have lumbar spine CT scans at baseline, 12 months, and 24
months, lumbar spine magnetic resonance imaging at baseline and 12 months, and spinal
radiographs at baseline, 12 months, 24 months, and 48 months. In addition, clinical
assessments will be done every 4 months during the first 24 months. An option to perform only
the baseline studies is also possible. No treatment is provided in the protocol. Reliability
of image processing will be tested on repeated measurements of baseline scans. Reliability
will also be assessed with repeat CT scans on up to 10 participants. Construct validity will
be tested by correlation of CT measures with scores of plain radiographs, lumbar magnetic
resonance imaging, and spinal range of motion. The sensitivity to change of the CT measures
over 12 months and 24 months will be compared to those of two scoring systems based on plain
radiographs.
spondylitis (AS). However, spinal fusion occurs slowly in AS. Serial radiographs rarely show
changes over 2 years, and often 5 or more years are needed to demonstrate progression of
spinal fusion. Methods that are more sensitive to changes in the extent of spinal fusion than
plain radiographs are needed to test if any treatments can slow or halt spinal fusion in AS.
The need for an improved measure of spinal fusion is heightened now that several new
medications are available that have the potential to markedly decrease spinal inflammation in
AS.
The goal of this pilot study is to test whether measurement of bone mineral density, bone
volume, or bone mass at the annulus fibrosis of lumbar disc spaces by computed tomography
(CT) can provide a reliable, valid, and sensitive measure of spinal fusion in patients with
AS. Fifty-five participants will have lumbar spine CT scans at baseline, 12 months, and 24
months, lumbar spine magnetic resonance imaging at baseline and 12 months, and spinal
radiographs at baseline, 12 months, 24 months, and 48 months. In addition, clinical
assessments will be done every 4 months during the first 24 months. An option to perform only
the baseline studies is also possible. No treatment is provided in the protocol. Reliability
of image processing will be tested on repeated measurements of baseline scans. Reliability
will also be assessed with repeat CT scans on up to 10 participants. Construct validity will
be tested by correlation of CT measures with scores of plain radiographs, lumbar magnetic
resonance imaging, and spinal range of motion. The sensitivity to change of the CT measures
over 12 months and 24 months will be compared to those of two scoring systems based on plain
radiographs.
- A. LONGITUDINAL STUDY PROTOCOL:
Fifty-five patients will be studied.
INCLUSION CRITERIA:
1. Age 18 years or older
2. Diagnosis of AS by the modified New York criteria
3. Lumbar spine BASRI score of 0, 1, 2, or 3
We will aim to recruit at least 6 patients in each of the following BASRI lumbar spine
categories:
- 0 or 1 (normal or suspicious changes)
- 2 (erosions, sclerosis or squaring with or without syndesmophytes or 2 or fewer
vertebrae)
- 3 (syndesmophytes on 3 or more vertebrae with fusion of at most 2 vertebrae)
EXCLUSION CRITERIA:
1. Inability to provide informed consent.
2. BASRI lumbar spine score of 4 (complete fusion; 12)
3. Contraindication to MRI scanning based on the NMR Center MRI Safety Screening
Questionnaire or size or weight limitations of the scanner.
4. History of allergic reactions to gadolinium-DPTA contrast used for MRI
5. Anticipated unavailability for follow-up over 2 years
6. Pregnancy
7. Onset of AS at age 16 or younger
8. Spondyloarthropathy other than AS
9. Severe scoliosis or other spinal malalignment that would complicate scan
interpretation
B. CROSS-SECTIONAL (RELIABILITY) STUDY PROTOCOL
Up to 35 patients will be studied.
INCLUSION CRITERIA:
1. Age 18 years or older
2. Diagnosis of AS by the modified New York criteria (5)
EXCLUSION CRITERIA:
1. Inability to provide informed consent
2. BASRI lumbar spine score of 4 (complete fusion)
3. Pregnancy
4. Onset of AS at age 16 or younger
5. Spondyloarthropathy other than AS
6. Severe scoliosis or other spinal malalignment that would complicate scan
interpretation
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
Phone: 800-411-1222
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