Posterior Cingulate Function in Persons With Risk Factors for Alzheimer's Disease
| Status: | Completed |
|---|---|
| Conditions: | Alzheimer Disease, Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 55 - 65 |
| Updated: | 4/21/2016 |
| Start Date: | July 2005 |
| End Date: | October 2007 |
The purpose of this study is to use fMRI techniques to explore a certain part of the brain
associated with Alzheimer's disease known as the posterior cingulate. Determining the
functionality of this brain region may help us diagnose AD more accurately, thus allowing
earlier treatment.
associated with Alzheimer's disease known as the posterior cingulate. Determining the
functionality of this brain region may help us diagnose AD more accurately, thus allowing
earlier treatment.
The posterior cingulate is a key brain region suggested by recent studies to be affected in
people at risk for Alzheimer's Disease (AD). Because the PC is affected very early in the
course of AD and the region may have reduced function even prior to the onset of symptoms,
further understanding of its functional role and its relationship to other brain regions may
be helpful in detecting AD earlier and in monitoring disease progression and treatment. This
project examines the role of the PC and its connections to other brain regions using
functional magnetic resonance imaging (fMRI), a technique that allows us to examine the
brain at work during tests of memory and decision-making. The main goal is to see if
functional connections between brain regions are modulated by risk for AD.
people at risk for Alzheimer's Disease (AD). Because the PC is affected very early in the
course of AD and the region may have reduced function even prior to the onset of symptoms,
further understanding of its functional role and its relationship to other brain regions may
be helpful in detecting AD earlier and in monitoring disease progression and treatment. This
project examines the role of the PC and its connections to other brain regions using
functional magnetic resonance imaging (fMRI), a technique that allows us to examine the
brain at work during tests of memory and decision-making. The main goal is to see if
functional connections between brain regions are modulated by risk for AD.
Inclusion Criteria:
- Cognitively healthy
- (Controls Only) Parents survived past age 70 and did/do not have memory problems.
Exclusion Criteria:
- Claustrophobia
- Metallic or electronic implants
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